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Browsing by Author "Fahmy, Sherif Ashraf"
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Box–Behnken design of thermo-responsive nano-liposomes loaded with a platinum( iv ) anticancer complex: evaluation of cytotoxicity and apoptotic pathways in triple negative breast cancer cells †
Sedky, Nada K.; Braoudaki, Maria; Mahdy, Noha Khalil; Amin, Kenzy; Fawzy, Iten M.; Efthimiadou, Eleni K.; Youness, Rana A.; Fahmy, Sherif Ashraf (2023-09-15)Herein, thermo-responsive liposomes (TLs) loaded with Asp (Asp/TLs) were produced by self-assembling DPPC, DSPE-PEG2000, and cholesterol. The preparation variables were optimized using the Box–Behnken design (BBD). The ... -
Molecular Engines, Therapeutic Targets, and Challenges in Pediatric Brain Tumors: A Special Emphasis on Hydrogen Sulfide and RNA-Based Nano-Delivery
Fahmy, Sherif Ashraf; Dawoud, Alyaa; Zeinelabdeen, Yousra Ahmed; Kiriacos, Caroline Joseph; Daniel, Kerolos Ashraf; Eltahtawy, Omar; Abdelhalim, Miriam Mokhtar; Braoudaki, Maria; Youness, Rana A. (2022-10-26)Pediatric primary brain tumors represent a real challenge in the oncology arena. Besides the psychosocial burden, brain tumors are considered one of the most difficult-to-treat malignancies due to their sophisticated ... -
A Novel Epigenetic Strategy to Concurrently Block Immune Checkpoints PD-1/PD-L1 and CD155/TIGIT in Hepatocellular Carcinoma
Assal, Reem A.; Elemam, Noha M.; Mekky, Radwa Y.; Attia, Abdelrahman A.; Soliman, Aya Hesham; Gomaa, Asmaa Ibrahim; Efthimiadou, Eleni K.; Braoudaki, Maria; Fahmy, Sherif Ashraf; Youness, Rana A. (2024-04-17)Tumor microenvironment is an intricate web of stromal and immune cells creating an immune suppressive cordon around the tumor. In hepatocellular carcinoma (HCC), Tumor microenvironment is a formidable barrier towards novel ... -
Oral Delivery of Psoralidin by Mucoadhesive Surface-Modified Bilosomes Showed Boosted Apoptotic and Necrotic Effects against Breast and Lung Cancer Cells
Youness, Rana Ahmed; Al-Mahallawi, Abdulaziz Mohsen; Mahmoud, Farah Haytham; Atta, Hind; Braoudaki, Maria; Fahmy, Sherif Ashraf (2023-03-15)This study aims to design and optimize chitosan-coated bilosomal formulations loaded with psoralidin (Ps-CS/BLs) with improved physicochemical properties, oral bioavailability, and boosted apoptotic and necrotic effects. ... -
A Snapshot of photoresponsive liposomes in cancer chemotherapy and immunotherapy: opportunities and challenges
Youness, Rana A.; Hasan, Adham; Efthimiadou, Eleni; Mekky, Radwa; Braoudaki, Maria; Fahmy, Sherif Ashraf (2023-11-28)To provide precise medical regimens, photonics technologies have been involved in the field of nanomedicine. Phototriggered liposomes have been cast as promising nanosystems that achieve controlled release of payloads in ...