Browsing by Author "Farrington, Kenneth"

Now showing items 1-20 of 41

    • 2-oxothiazolidine-4-carboxylic acid inhibits vascular calcification via induction of glutathione synthesis 

      Patel, Jessal; Bourne, Lucie E; Thakur, Shori; Farrington, Kenneth; Gorog, Diana; Orriss, Isabel R; Baydoun, Anwar (2020-09-12)
      Arterial medial calcification (AMC), the deposition of hydroxyapatite in the medial layer of the arteries, is a known risk factor for cardiovascular events. Oxidative stress is a known inducer of AMC and endogenous ...

    • Acute Haemodynamic Changes During Haemodialysis Do Not Exacerbate Gut Hyperpermeability 

      Wong, Jonathan; Lenaerts, Kaatje; Meesters, Dennis; Olde Damink, Steven; Van Eijk, Hans; Vilar Hall, Enric; Farrington, Kenneth (2019-04-12)
      Introduction: The gastrointestinal tract is a potential source of inflammation in dialysis patients. In-vitro studies suggest breakdown of the gut barrier in uraemia leading to increased intestinal permeability and it is ...

    • Adherence Behavior in Subjects on Hemodialysis Is Not a Clear Predictor of Posttransplantation Adherence 

      Hucker, Abigail; Lawrence, Christopher; Sharma, Shivani; Farrington, Kenneth (2019-08-01)
      Introduction: Nonadherence is common in both hemodialysis (HD) and kidney transplant recipients and is a major risk factor for poor clinical outcomes. This retrospective study explored whether nonadherent HD patients become ...

    • An Analysis of Vascular Access Thrombosis Events From the Proactive IV irOn Therapy in hemodiALysis Patients Trial 

      PIVOTAL investigators and committees; Farrington, Kenneth (2022-08-01)
      Introduction: Treatment of anemia in dialysis patients has been associated with increased risk of vascular access thrombosis (VAT). Proactive IV irOn Therapy in hemodiALysis Patients (PIVOTAL) was a clinical trial of ...

    • Antidepressant Usage in Haemodialysis Patients: Evidence of Sub-optimal Practice Patterns 

      Guirguis, Ayman; Almond, Michael; Chilcot, Joseph; Davenport, A.; Wellsted, David; Farrington, Kenneth (2020-06-01)
      Background: Depression is common in patients on haemodialysis and associated with adverse outcomes. Antidepressant use is widespread though evidence of efficacy is limited. Objectives: To study antidepressant management ...

    • Care pathways for the identification and management of depression in patients with chronic kidney disease: a rapid scoping review 

      Hall, Natalie; Pearce, Christina; Hudson, Joanna; Farrington, Kenneth; Wellsted, David; Jones, Julia; Sharma, Shivani; Norton, Sam; Ormandy, Paula; Palmer, Nick; Chilcot, Joe (2021-11-11)
      Depression is highly prevalent across the spectrum of Chronic Kidney Disease (CKD) and related to poor clinical outcomes. There is limited evidence regarding the most effective and acceptable interventions to manage ...

    • A comparative study of blood endotoxin detection in haemodialysis patients 

      Wong, Jonathan; Davies, Nathan; Jeraj, Hasan; Vilar, Enric; Viljoen, Adie; Farrington, Kenneth (2016-07-30)
      BACKGROUND: Endotoxemia is commonly reported in patients receiving haemodialysis and implicated in the pathogenesis of systemic inflammation. The Limulus Amoebocyte Lysate (LAL) assay is the most commonly used blood endotoxin ...

    • Contributions of treatment centre and patient characteristics to patient-reported experience of haemodialysis: A national cross-sectional study 

      Hawkins, Janine; Smeeton, Nigel; Busby, Amanda; Wellsted, David; Rider, Beth; Jones, Julia; Steinkamp, Retha; Stannard, Catherine; Gair, Rachel; Van Der Veer, Sabine; Corps, Claire; Farrington, Kenneth (2021-04-14)
      OBJECTIVES: To examine the relative importance of patient and centre level factors in determining self-reported experience of care in patients with advanced kidney disease treated by maintenance haemodialysis (HD). DESIGN: ...

    • Diabetes confers in vitro calcific potential on serum which associates with in-vivo vascular calcification 

      Patidar, Ashish; Singh, Dhruv; Thakur, Shori; Winocour, Peter; Farrington, Kenneth; Baydoun, Anwar (2017-05-09)
      Although vascular calcification (VC) is prevalent in Type 2 diabetes mellitus (T2DM), underlying mechanisms remain unclear. Neither is it known whether T2DM confers calcific potential (CP) on serum, enabling it to induce ...

    • Endotoxemia in end-stage kidney disease 

      Wong, Jonathan; Vilar, Enric; Farrington, Kenneth (2015-01-08)
      Chronic unexplained inflammation remains a prevalent and clinically significant problem for patients with end-stage kidney disease (ESKD), especially in the dialysis population. The causes of persistent inflammation are ...

    • Endotoxin detection in end-stage kidney disease 

      Wong, Jonathan; Jeraj, Hassan; Vilar, Enric; Viljoen, Adie; Farrington, Kenneth (2015-01-01)
      Aims: Endotoxin detection assays are not validated for use in end-stage kidney disease (ESKD). We investigated the accuracy and precision of the kinetic turbidimetric Limulus amoebocyte lysate (LAL) assay to detect endotoxin ...

    • The identification and management of depression in UK Kidney Care: Results from the Mood Maps Study 

      Chilcot, Joe; Pearce, Christina; Hall, Natalie; Busby, Amanda; Hawkins, Janine; Vraitch, Balvinder; Rathjen, Mandy; Hamilton, Alexander; Bevin, Amanda; Mackintosh, Lucy; Hudson, Joanna; Wellsted, David; Jones, Julia; Sharma, Shivani; Norton, Sam; Ormandy, Paula; Palmer, Nick; Farrington, Kenneth (2024-02-11)
      Background Depression is common in people with chronic kidney disease, yet little is known about how depression is identified and managed as part of routine kidney care. Objectives The primary objective was to survey all ...

    • Illness perceptions of Turkish Cypriot patients receiving haemodialysis: A qualitative study 

      Keskindag, Buse; Farrington, Kenneth; Oygar, Duriye; Mertan, Biran; Hucker, Abigail; Sharma, Shivani (2020-10-10)
      Background: Illness perceptions refer to cognitive appraisals that help patients understand and make sense of their condition. Although their importance in health behaviour and outcomes has been evidenced, less is known ...

    • Impact of COVID-19 on Patient Experience of Kidney Care: A Rapid Review 

      Mackintosh, Lucy; Ormandy, Paula; Busby, Amanda; Hawkins, Janine; Klare, Ranjit; Silver, Christina; Da Silva-Gane, Maria; Santhakumaran, Shalini; Bristow, Paul; Sharma, Shivani; Wellsted, David; Chilcot, Joseph; Sridharan, Sivakumar; Steinkamp, Retha; Harris, Tess; Muirhead, Susan; Lush, Vicky; Afuwape, Sarah; Farrington, Kenneth (2023-12-20)
      Background In March 2020 a pandemic state was declared due to SARS-COV-2 (COVID-19). Patients with kidney disease, especially those on replacement therapies, proved more susceptible to severe infection. This rapid literature ...

    • Impact of incremental initiation of haemodialysis on mortality: a systematic review and meta-analysis 

      Caton, Emma; Sharma, Shivani; Vilar, Enric; Farrington, Kenneth (2023-02-28)
      Background Incremental haemodialysis initiation entails lower sessional duration and/or frequency than the standard 4 h thrice-weekly approach. Dialysis dose is increased as residual kidney function (RKF) declines. This ...

    • Impact of the COVID-19 pandemic on Services for Patients with Chronic Kidney Disease: Findings of a National Survey of UK Kidney Centres 

      Mackintosh, Lucy; Busby, Amanda; Farrington, Kenneth; Hawkins, Janine; Afuwape, Sarah; Bristow, Paul; Da Silva-Gane, Maria; Hall, Natalie; Harris, Tess; Hudson, Joanna; Norton, Sam; Ormandy, Paula; Pearce, Christina J.; Santhakumaran, Shalini; Sharma, Shivani; Sridharan, Sivakumar; Steenkamp, Retha; Slevin, Julie; Wellsted, David; Chilcot, Joseph (2023-12-04)
      Background Services for patients with kidney disease underwent radical adaptations in response to the COVID-19 pandemic. We undertook an online national survey of UK kidney centres to understand the nature, range, and ...

    • Incremental haemodialysis 

      Wong, Jonathan; Vilar, Enric; Davenport, Andrew; Farrington, Kenneth (2015-06-01)
      Thrice-weekly haemodialysis schedules have become the standard default haemodialysis prescription worldwide. Whereas the measurement of residual renal function is accepted practice for peritoneal dialysis patients and the ...

    • Indexing Dialysis Dose for Gender, Body size and Physical Activity: Impact on Survival 

      Sridharan, Sivakumar; Wellsted, David; Vilar, Enric; Davenport, Andrew; Ashman, Neil; K Almond, Michael; Banerjee, Anindya; Roberts, Justin; Farrington, Kenneth (2018-07-25)
      Background Current practice basing dialysis dose on urea distribution volume (V), has been questioned. We explored the impact on survival of scaling dialysis dose (Kt) to parameters reflective of metabolic activity. ...

    • Indexing dialysis dose for gender, body size and physical activity: Impact on survival 

      Sridharan, Sivakumar; Vilar Hall, Enric; Davenport, Andrew; Ashman, Neil; Almond, Michael; Banerjee, Anindya; Justin, Roberts,; Farrington, Kenneth (2018-09-07)
      Current practice basing dialysis dose on urea distribution volume (V) has been questioned. We explored the impact on survival of scaling dialysis dose (Kt) to parameters reflective of metabolic activity. In a multicentre ...

    • Intravenous Iron Dosing and Infection Risk in Patients on Hemodialysis : A Prespecified Secondary Analysis of the PIVOTAL Trial 

      PIVOTAL investigators and committees; Farrington, Kenneth (2020-05)
      BACKGROUND: Experimental and observational studies have raised concerns that giving intravenous (IV) iron to patients, such as individuals receiving maintenance hemodialysis, might increase the risk of infections. The ...