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Browsing by Author "Fiala, Sarah"
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Dynamic in-situ eutectic formation for topical drug delivery
Fiala, Sarah; Brown, Marc; Jones, Stuart A. (2011-11)Objectives: The relationship between the solution-state chemistry of eutectic systems and their transmembrane transport characteristics is difficult to define as these mixtures are sensitive to delivery vehicle-induced ... -
A fundamental investigation into the effects of eutectic formation on transmembrane transport
Fiala, Sarah; Jones, Stuart A.; Brown, Marc (2010-06-30)Eutectic systems enhance the permeation of therapeutic agents across biological barriers, but the mechanism by which this occurs has not previously been elucidated. Using human skin it has proven difficult to isolate the ... -
An investigation into the influence of binary drug solutions upon diffusion and partition processes in model membranes
Fiala, Sarah; Brown, Marc; Jones, Stuart A. (2008-12)Few studies have assessed the impact of binary systems on the fundamental mathematical models that describe drug permeation. The aim of this work was to determine the influence of varying the proportions of prilocaine and ... -
New insights into eutectic cream skin penetration enhancement
Fiala, Sarah; Roman, Marie; Inacio, Ricardo; Mashal, Sumaia; Brown, Marc B; Jones, Stuart A (2016-02-29)The manner in which the eutectic cream EMLA enhances the percutaneous penetration of lidocaine and prilocaine into human skin is still not fully understood. The purpose of this study was to investigate if the modification ...