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Browsing by Author "Floresta, Giuseppe"
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Benzodiazepine Boom: Tracking Etizolam, Pyrazolam, and Flubromazepam from Pre-UK Psychoactive Act 2016 to Present Using Analytical and Social Listening Techniques
Mullin, Anthony; Scott, Mark; Vaccaro, Giorgia; Floresta, Giuseppe; Arillotta, Davide; Catalani, Valeria; Corkery, John M; Stair, Jacqueline L; Schifano, Fabrizio; Guirguis, Amira (2024-01-12)Introduction: The designer benzodiazepine (DBZD) market continues to expand whilst evading regulatory controls. The widespread adoption of social media by pro-drug use communities encourages positive discussions around ... -
Evidence-based successful example of a structure-based approach for the prediction of designer fentanyl-like molecules
Floresta, Giuseppe; Catalani, Valeria; Abbate, Vincenzo (2024-12)In 2019, we published three innovative quantitative structure-activity relationship models (QSAR) for predicting the affinity of mu-opioid receptor (µOR) ligands. The three different models were then combined to produce a ... -
Exploring the Association Between Suicidal Thoughts, Self-Injury, and GLP-1 Receptor Agonists in Weight Loss Treatments: Insights from Pharmacovigilance Measures and Unmasking Analysis
Guirguis, Amira; Chiappini, Stephania; Papanti, P G Duccio; Vickers-Smith, Rachel; Harris, Daniel; Corkery, John; Arillotta, Davide; Floresta, Giuseppe; Martinotti, Giovanni; Schifano, Fabrizio (2024-05)Introduction: The study addresses concerns about potential psychiatric side effects of Glucagon-like peptide-1 receptor agonists (GLP-1 RA). Aim: The aim of this work was to analyse adverse drug reports (ADRs) from the ... -
GLP-1 Receptor Agonists and Related Mental Health Issues; Insights from a Range of Social Media Platforms Using a Mixed-Methods Approach
Arillotta, Davide; Floresta, Giuseppe; Guirguis, Amira; Corkery, John Martin; Catalani, Valeria; Martinotti, Giovanni; Sensi, Stefano L.; Schifano, Fabrizio (2023-10-24)The emergence of glucagon-like peptide-1 receptor agonists (GLP-1 RAs; semaglutide and others) now promises effective, non-invasive treatment of obesity for individuals with and without diabetes. Social media platforms’ ... -
In silico studies on recreational drugs: 3D quantitative structure activity relationship prediction of classified and de novo designer benzodiazepines
Catalani, Valeria; Floresta, Giuseppe; Botha, Michelle; Corkery, John Martin; Guirguis, Amira; Vento, Alessandro; Abbate, Vincenzo; Schifano, Fabrizio (2022-07-15)Currently, increasing availability and popularity of designer benzodiazepines (DBZDs) constitutes a primary threat to public health. To assess this threat, the biological activity/potency of DBZDs was investigated using ... -
Semaglutide as a Possible Calmodulin Binder: Ligand-Based Computational Analyses and Relevance to Its Associated Reward and Appetitive Behaviour Actions
Floresta, Giuseppe; Arillotta, Davide; Catalani, Valeria; Papanti Pelletier, G. Duccio; Corkery, John; Guirguis, Amira; Schifano, Fabrizio (2024-03-22)Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, has gained considerable attention as a therapeutic agent for type 2 diabetes mellitus and obesity. Despite its clinical success, the precise mechanisms ...