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Browsing by Author "Forbes, B."
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Activation of clindamycin phosphate by human skin
Amr, S.; Brown, Marc; Martin, Gary P.; Forbes, B. (2001-04)Aims: To investigate the relative antimicrobial activity of clindamycin phosphate (CP) and clindamycin (Cly) and to examine the effect of skin homogenates on the activity of CP. Methods and Results: Minimum inhibitory ... -
The effect of aerodynamic particle size and solid state disorder on salmeterol xinafoate deposition from pressurised metered dose and dry powder inhaler formulations
Jaffari, S.; Sandhu, G.; Martin, G. P.; Forbes, B.; Collins, E.; Murnane, D. (2013-08)The production of active pharmaceutical ingredients (APIs) generally consists of crystallisation followed by a comminution process which provides limited control over particle size and energises particle surfaces. Both ... -
Hyaluronan: Pharmaceutical characterization and drug delivery
Liao, Y. H.; Jones, Stuart A.; Forbes, B.; Martin, Gary P.; Brown, Marc (2005)Hyaluronic acid ( HA), is a polyanionic polysaccharide that consists of N-acetyl-D-glucosamine and beta-glucoronic acid. It is most frequently referred to as hyaluronan because it exists in vivo as a polyanion and not in ... -
In vitro efficacy of a non-alcoholic antibacterial cleansing lotion as a potential routine hand disinfectant
Turner, R.; Lim, S.; Forbes, B.; Brown, Marc (2006-09) -
An in vitro technique for evaluating inhaled nasal delivery systems
Forbes, B.; Lim, S.; Martin, Gary P.; Brown, Marc (2002)This report describes a novel technique for delivering aerosols to the surface of respiratory epithelial cells cultured tit an air-liquid interface. A model microsphere formulation for nasal delivery was aerosolised using ... -
In vivo evaluation of novel hyaluronan/chitosan microparticulate delivery systems for the nasal delivery of gentamicin in rabbits
Lim, S. T.; Forbes, B.; Berry, D. J.; Martin, Gary P.; Brown, Marc (2002-01)Biodegradable microparticles containing gentamicin were prepared using chitosan hydroglutamate (CH), hyaluronic acid (HA) and a combination Of both polymers by a solvent evaporation method. These formulations were administered ... -
Mitigation of surfactant erythrocyte toxicity by egg phosphatidylcholine
Gould, L. A.; Lansley, A. B.; Brown, Marc; Forbes, B.; Martin, Gary P. (2000-10)Polyoxyethylene alkyl ether surfactants have been shown to have excellent penetration enhancing abilities although they are associated with a high level of local toxicity. We have compared the toxicity of a range of ... -
Nail swelling as a pre-formulation screen for the selection and optimisation of ungual penetration enhancers
Khengar, R. H.; Jones, S. A.; Turner, R. B.; Forbes, B.; Brown, Marc (2007-12)Introduction. Targeting drug treatment to fungal infections that reside within or below the nail plate is problematic due to the highly restrictive barrier of the human nail. To optimise topical formulations for ungual ... -
Overcoming the nail barrier : A systematic investigation of ungual chemical penetration enhancement
Brown, Marc; Khengar, Rajeshree H.; Turner, Rob B.; Forbes, B.; Traynor, M.J.; Evans, C.R.G.; Jones, S. A. (2009-03-31)This study investigated the in vitro nail permeability of penetrants of varying lipophilicity—caffeine (CF, log P −0.07), methylparaben (MP, log P 1.96) and terbinafine (TBF, log P 3.3) and the effect of 2 novel penetration ...