Browsing by Author "Godwin, A."

Now showing items 1-2 of 2

    • Molecular dynamics simulations of proteins with chemically modified disulfide bonds 

      Godwin, A.; Pedone, E.; Balan, S.; Jumnah, R.; Brocchini, S.; Choi, J.-W.; Shaunak, S.; Zloh, Mire (2007-02)
      Proteins that are used as therapeutic drugs act in the extracellular microenvironment. They usually have a small number of intramolecular disulfide bonds to help maintain their tertiary structure in the vascular circulation. ...

    • Site-specific PEGylation of protein bisulfide bonds using a three-carbon bridge 

      Balan, S.; Godwin, A.; Laborde, C.M.; Brocchini, S.; Choi, J.-W.; Teo, I.; Shaunak, S.; Heidelberger, S.; Zloh, Mire (2007)
      The covalent conjugation of a functionalized poly(ethylene glycol) (PEG) to multiple nucleophilic amine residues results in a heterogeneous mixture of PEG positional isomers. Their physicochemical, biological, and ...