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Browsing by Author "Groot, P.H.E."
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CCR2: Characterization of the antagonist binding site from a combined receptor modeling/mutagenesis approach
Berkhout, Theo; Blaney, F.E.; Bridges, A.M.; Cooper, D.G.; Forbes, I.T.; Gribble, A.D.; Groot, P.H.E.; Hardy, A.; Ife, R.J.; Kaur, R.; Moores, K.E.; Shillito, H.; Willetts, J.; Witherington, J. (2003-09-11)We describe here a classical molecular modeling exercise that was carried out to provide a basis for the design of novel antagonist ligands of the CCR2 receptor. Using a theoretical model of the CCR2 receptor, docking ... -
The effect of (-)-hydroxycitrate and mevinolin on the activity of the low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl-coenzyme A reductase in the human hepatoma Hep G2
Berkhout, Theo; Groot, P.H.E.; Havekes, Louis M.; Pearce, N. J. (W. Zuckwerdt Verlag, 1992) -
The effect of (-)-hydroxycitrate on the activity of the low-density-lipoprotein receptor and 3-hydroxy-3-methylglutaryl-CoA reductase levels in the human hepatoma cell line Hep G2
Berkhout, Theo; Havekes, Louis M.; Pearce, N. J.; Groot, P.H.E. (1990)(-)-Hydroxycitrate, a potent inhibitor of ATP citrate-lyase, was tested in Hep G2 cells for effects on cholesterol homoeostasis. After 2.5 h and 18 h incubations with (-)-hydroxycitrate at concentrations of 0.5 mM or higher, ...