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Browsing by Author "Grundy, D."
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Afferent hypersensitivity in a mouse model of post-inflammatory gut dysfunction : role of altered serotonin metabolism
Keating, Christopher; Beyak, M.; Foley, S.; Singh, G.; Marsden, C.; Spiller, R.; Grundy, D. (2008-09)Visceral hypersensitivity is an important clinical feature associated with irritable bowel syndrome which in some patients has been linked to prior infection. Here we employ an animal model in which transient infection ... -
The effect of prolonged CLP-induced sepsis on jejunal mesenteric afferent nerve activity in mice
Nullens, Sarah; Deiteren, Annemie; de Man, Joris; Keating, Christopher; Jiang, Wen; Grundy, D.; de Winter, Benedicte (2015-06) -
P2X 7 receptor-dependent intestinal afferent hypersensitivity in a mouse model of postinfectious irritable bowel syndrome
Keating, Christopher; Pelegrin, P.; Martínez, C.M.; Grundy, D. (2011-08-01)The ATP-gated P2X7 receptor (P2X7R) was shown to be an important mediator of inflammation and inflammatory pain through its regulation of IL-1β processing and release. Trichinella spiralis-infected mice develop a ...