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Browsing by Author "Haddon, C. O."
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3-Nitrotyrosine-dependent dopaminergic neurotoxicity following direct nigral administration of a peroxynitrite but not a nitric oxide donor
Iravani, Mahmoud M.; Haddon, C. O.; Rose, S.; Jenner, P. (2006-01-05)The presence of 3-nitrotyrosine (3-NT) adducts in Lewy bodies in Parkinson's disease suggests a role for nitrative stress in dopaminergic cell death. Whether this is a direct effect of increased nitric oxide (NO) formation ... -
The acute and the long-term effects of nigral lipopolysaccharide administration on dopaminergic dysfunction and glial cell activation
Iravani, Mahmoud M.; Leung, Clement C. M.; Sadeghian, Mona; Haddon, C. O.; Rose, Sarah; Jenner, P. (2005-07)Sustained reactive microgliosis may contribute to the progressive degeneration of nigral dopaminergic neurons in Parkinson's disease (PD), in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exposed human and in non-human ... -
Pramipexole protects against MPTP toxicity in non-human primates
Iravani, Mahmoud M.; Haddon, C. O.; Cooper, J. M.; Jenner, P.; Schapira, A. H. (2006-03)The neurotoxin MPTP induces nigral dopaminergic cell death in primates and produces a partial model of Parkinson's disease (PD). Pramipexole is a D-2/D-3 dopamine receptor agonist used in the symptomatic treatment of PD, ...