Browsing by Author "Hamilton, Alexander"

Now showing items 1-3 of 3

    • Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production 

      Knudsen, Jakob G; Hamilton, Alexander; Ramracheya, Reshma; Tarasov, Andrei I; Brereton, Melissa; Haythorne, Elizabeth; Chibalina, Margarita V; Spégel, Peter; Mulder, Hindrik; Zhang, Quan; Ashcroft, Frances M; Adam, Julie; Rorsman, Patrik (2019-02-05)
      Diabetes is a bihormonal disorder resulting from combined insulin and glucagon secretion defects. Mice lacking fumarase (Fh1) in their β cells (Fh1βKO mice) develop progressive hyperglycemia and dysregulated glucagon ...

    • The identification and management of depression in UK Kidney Care: Results from the Mood Maps Study 

      Chilcot, Joe; Pearce, Christina; Hall, Natalie; Busby, Amanda; Hawkins, Janine; Vraitch, Balvinder; Rathjen, Mandy; Hamilton, Alexander; Bevin, Amanda; Mackintosh, Lucy; Hudson, Joanna; Wellsted, David; Jones, Julia; Sharma, Shivani; Norton, Sam; Ormandy, Paula; Palmer, Nick; Farrington, Kenneth (2024-02-11)
      Background Depression is common in people with chronic kidney disease, yet little is known about how depression is identified and managed as part of routine kidney care. Objectives The primary objective was to survey all ...

    • Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion 

      Vergari, Elisa; Knudsen, Jakob G; Ramracheya, Reshma; Salehi, Albert; Zhang, Quan; Adam, Julie; Asterholm, Ingrid Wernstedt; Benrick, Anna; Briant, Linford J B; Chibalina, Margarita V; Gribble, Fiona M; Hamilton, Alexander; Hastoy, Benoit; Reimann, Frank; Rorsman, Nils J G; Spiliotis, Ioannis I; Tarasov, Andrei; Wu, Yanling; Ashcroft, Frances M; Rorsman, Patrik (2019-01-11)
      Hypoglycaemia (low plasma glucose) is a serious and potentially fatal complication of insulin-treated diabetes. In healthy individuals, hypoglycaemia triggers glucagon secretion, which restores normal plasma glucose levels ...