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Browsing by Author "Harries, M."
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Capsazepine protects against neuronal injury caused by oxygen glucose deprivation by inhibiting Ih
Ray, A.; Benham, C.D.; Roberts, J.C.; Gill, C.H.; Lanneau, C.; Gitterman, D.P.; Harries, M.; Davis, J.B.; Davies, C.H. (2003) -
Characterisation of SB-221420-A, a neuronal Ca and Na channel antagonist in experimental models of stroke
Campbell, C.A.; Barone, F.C.; Benham, C.D.; Hadingham, S.J.; Harries, M.; Hills, J.M.; Lewis, V.A.; Parsons, A.A.; White, R.F.; Hunter, A.J. (2000) -
Cloning and functional expression of a human orthologue of the rat vanilloid receptor-1
Hayes, P.; Meadows, H.J.; Gunthorpe, M.J.; Harries, M.; Duckworth, M.; Cairns, W.; Harrison, D. C.; Ellington, K.; Prinjha, R.; Barton, A.; Medhurst, A.D.; Smith, G.D.; Topp, S.; Sanger, G.; Jenkins, O.; Benham, C.D.; Gloger, I.; Clarke, C. E.; Murdock, P.; Terrett, J.; Randall, A. D.; Gloger, I. S.; Davis, J. B. (2000-11-01)Capsaicin, resiniferatoxin, protons or heat have been shown to activate an ion channel, termed the rat vanilloid receptor-1 (rVR1), originally isolated by expression cloning for a capsaicin sensitive phenotype. Here we ... -
The effects of SB 206284A, a novel neuronal Ca channel antagonist in models of cerebral ischaemia
Wood, N.; Barone, F.C.; Benham, C.D.; Brown, T.H.; Campbell, C.A.; Cooper, D.C.; Evans, M.L.; Feuerstein, G.; Hamilton, T.C.; Harries, M.; King, P.D.; Meakin, J.E.; Murkitt, J.L.; Patel, S.; Price, W.J.; Roberts, J.C.; Rothaul, A.L.; Samson, N.A.; Smith, S.J.; Hunter, A.J. (1997)The effects of SB 206284A, 1-[7-(4-benzyloxyphenoxy)heptyl] piperidine hydrochloride, have been investigated in vitro on calcium and sodium currents in rat-cultured dorsal root ganglion (DRG) neurones and potassium-mediated ... -
Rank-order inhibition by ω-conotoxins in human and animal autonomic nerve preparations
Sanger, G.; Ellis, E.S.; Harries, M.; Tilford, N.S.; Wardle, K.A.; Benham, C.D. (2000)The inhibitory effects of the ω-conotoxins GVIA, MVIIA and MVIIC on electrically-evoked, tetrodotoxin (10−7 M)-sensitive, autonomic nerve activity were studied using human, rat or guinea-pig vas deferens and intestinal ... -
SB 201823-A antagonises calcium currents in central neurons and reduces the effects of focal ischaemia in rats and mice
Barone, F.C.; Lysko, P. G.; Price, W.J.; Feuerstein, G.; Benham, C.D.; Harrison, D. C.; Harries, M.; Bailey, S. J.; Hunter, A.J. (1995) -
SB 201823-A, A neuronal Ca antagonist is neuroprotective in two models of cerebral ischaemia
Benham, C.D.; Brown, T.H.; Cooper, D.C.; Evans, M.L.; Harries, M.; Herdon, H.J.; Meakin, J.E.; Murkitt, K.L.; Patel, S.; Roberts, J.C.; Rothaul, A.L.; Smith, S.J.; Wood, N.; Hunter, A.J. (1993)We have characterised the Ca2+ channel blocking properties of a new non-peptide Ca2+ channel antagonist, SB 201823-A, in cultures of rat sensory neurones. The IC50 for SB 201823-A against total Ca2+ current in sensory ... -
SB 205384 slows the decay of GABA-activated chloride currents in granule cells cultured from rat cerebellum
Meadows, H.J.; Harries, M.; Thompson, M.; Benham, C.D. (1997)4-Amino-7-hydroxy-2-methyl-5,6,7,8,-tetrahydrobenzo[b]thieno[2,3-b]pyridine-3-carboxylic acid, but-2-ynyl ester (SB-205384) and other γ-aminobutyric acidA (GABAA) receptor modulators were tested for their effects on ... -
SB-334867-A antagonises orexin mediated excitation in the locus coeruleus
Soffin, E.M.; Evans, M.L.; Gill, C.H.; Harries, M.; Benham, C.D.; Davies, C.H. (2002)Electrophysiological recordings from identified noradrenergic locus coeruleus (LC) neurones in rat brain slices have revealed that the orexins can cause direct and reversible depolarisation of the postsynaptic membrane. ...