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Browsing by Author "Harrington, L.S."
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COX-1, and not COX-2 activity, regulates airway function : Relevance to aspirin-sensitive asthma
Harrington, L.S.; Lucas, R.; McMaster, S.K.; Moreno, L.; Scadding, G.; Mitchell, J.A.; Warner, T.D. (2008-11-01)Cyclooxygenase (COX) -1 and COX-2 are expressed in airway cells, where their activities influence functions such as airway hyperreactivity. Clinical data show that mixed COX-1/COX-2 inhibitors such as aspirin, but not COX-2 ... -
Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system
Kirkby, N.S.; Lundberg, M.H.; Harrington, L.S.; Leadbeater, P.D.M.; Potter, C.M.F.; Al-Yamani, M.; Adeyemi, O.; Mitchell, J.A.; Warner, T.D.; Milne, G.L. (2012-10-23)Prostacyclin is an antithrombotic hormone produced by the endothelium, whose production is dependent on cyclooxygenase (COX) enzymes of which two isoforms exist. It is widely believed that COX-2 drives prostacyclin production ... -
Elucidation of the temporal relationship between endothelial-derived NO and EDHF in mesenteric vessels
Harrington, L.S.; Mitchell, J.A.; Carrier, M.J.; Gallagher, N.; Garland, C.J.; Gilroy, D. (2007-09-01)Although the endothelium co-generates both nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF), the relative contribution from each vasodilator is not clear. In studies where the endothelium is stimulated ... -
Evidence for a specific influence of the nitrergic pathway on the peripheral pulse waveform in rabbits
Nier, B.A.; Harrington, L.S.; Carrier, M.J.; Weinberg, P.D. (2008-04-01)The height of the dicrotic notch between the systolic and diastolic peaks of the peripheral pulse wave, expressed as a fraction of the overall amplitude of the wave, is sensitive to nitric oxide (NO) bioactivity. This ... -
Homeostatic role of toll-like receptor 4 in the endothelium and heart
Harrington, L.S.; Belcher, E.; Moreno, L.; Mitchell, J.A.; Carrier, M.J. (2007-12)Toll-like receptor 4 (TLR4) is a pattern recognition receptor for lipopolysaccharide from Gram negative bacteria and thus is integral to the innate immune response in mammals. In addition, TLR4 is associated with atherosclerosis ... -
Novel role for P2X receptor activation in endothelium-dependent vasodilation
Harrington, L.S.; Mitchell, J.A. (2004-11-01)ATP is an important vasoactive mediator, which acts via two receptor classes: P2X and P2Y. Activation of P2X receptors has traditionally been associated with the well-characterised vasoconstrictor properties of ATP. In the ... -
P2X receptors and the endothelium
Harrington, L.S.; Mitchell, J.A. (2005)Adenosine triphosphate (ATP) is now established as a principle vaso-active mediator in the vasculature. Its actions on arteries are complex, and are mediated by the P2X and P2Y receptor families. It is generally accepted ... -
The PPARβ/δagonist GW0742 relaxes pulmonary vessels and limits right heart hypertrophy in rats with hypoxia-induced pulmonary hypertension
Harrington, L.S.; Moreno, L.; Reed, A.; Mitchell, J.A.; Wort, S.J.; Desvergne, B.; Garland, C.; Zhao, L. (2010-03-04)Background: Pulmonary vascular diseases are increasingly recognised as important clinical conditions. Pulmonary hypertension associated with a range of aetiologies is difficult to treat and associated with progressive ... -
Purinergic 2X receptors mediate endothelial dependent vasodilation to ATP
Harrington, L.S.; Ali, F.; Mitchell, J.A.; Wray, J.; Swales, K.E.; Norling, L.; Evans, R.J.; Vial, C.; Carrier, M.J. (2007-11)ATP is an important endogenous mediator in the cardiovascular system. It induces endothelium dependent vasodilation, but the precise receptor pathway activated in this response is currently under debate. We have used ... -
Reduced endothelial dependent vasodilation in vessels from TLR4 mice is associated with increased superoxide generation
Harrington, L.S.; Lundberg, M.H.; Waight, M.; Rozario, A.; Mitchell, J.A. (2011-05-20)Toll like receptor (TLR)4 is a pattern recognition receptor expressed in endothelial and other cells, responsible for the sensing of endotoxin and host derived ligands. Our group has shown previously that the absence of ... -
Role of nitric oxide and prostacyclin as vasoactive hormones released by the endothelium
Mitchell, J.A.; Ali, F.; Bailey, L.; Moreno, L.; Harrington, L.S. (2008-01)The endothelium lines the luminal surface of every blood vessel, allowing it contact with circulating blood elements, as well as the underlying vascular smooth muscle layer. In healthy vessels, the endothelium expresses ... -
Role of shear stress in endothelial cell morphology and expression of cyclooxygenase isoforms
Potter, C.M.F.; Lundberg, M.H.; Harrington, L.S.; Moshkov, A.V.; Gorelik, J.; Mitchell, J.A.; Warboys, C.M.; Weinberg, P.D.; Warner, T.D.; Berson, R.E. (2011-02)Objective-: The goal of this study was to examine the effect of chronic heterogeneous shear stress, applied using an orbital shaker, on endothelial cell morphology and the expression of cyclooxygenases 1 and 2. Methods and ...