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Browsing by Author "Hart, John E."
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Fecundity and lifespan manipulations in Caenorhabditis elegans using exogenous peptides
Davies, Keith G.; Hart, John E. (2008)In this study using Caenorhabditis elegans, we have been able to suppress (> 60%) and enhance (> 40%) fecundity (number of offspring) while extending lifespan by a fifth, by administering synthetic peptides to the aqueous ... -
Hexapeptides from mammalian inhibitory hormone hunt activate and inactivate nematode reproduction
Hart, John E.; Mohan, Sharad; Davies, Keith G.; Ferneyhough, Ben; Clarke, Iain J.; Hunt, John A.; Shnyder, Steve D.; Mundy, Christopher R.; Howlett, David R.; Newton, Russell P. (2022-12-01)Background: Biopurification has been used to disclose an evolutionarily conserved inhibitory reproductive hormone involved in tissue mass determination. A (rat) bioassay-guided physicochemical fractionation using ovine ... -
Reproduction potentiated in nematodes (Caenorhabditis elegans) and guppy fish (Poecilia reticulata) by adding a synthetic peptide to their aqueous environment
Davies, Keith G.; Zimmerman, Brian; Dudley, Ed; Newton, Russell; Hart, John E. (2015-03-01)Ambient exposure to a short synthetic peptide has enhanced fecundity (number of offspring) in invertebrates and vertebrates, ostensibly by disinhibiting reproduction. In separate experiments nematodes (Caenorhabditis ...