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Browsing by Author "Heffernan, S"
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Apolipoprotein E Ε4 allele is not associated with elite rugby status but is present in 30% of athletes
Heffernan, S; Kilduff, L; Erskine, R; Day, S; Stebbings, G; Cook, C; A, Grainger; Brazier, Jon; Antrobus, M; Williams, A (2018-07-04)The APOE ε4 allele is a candidate genetic marker for risk and severity of mild traumatic brain injury (mTBI) including sport-related concussion. ε4 allele carriers experience reduced motor rehabilitation outcomes, poorer ... -
Association between MAPT polymorphism but not APOE promoter and elite rugby athlete status
Antrobus, M; Brazier, Jon; Herbert, A; Stebbings, G; Day, S; Heffernan, S; Erskine, R; Kilduff, L; Williams, A (2018-07-04)INTRODUCTION: Incidence and outcomes of concussions have been hypothesised to be genetically influenced. The APOE Promoter G219T (rs405509) polymorphism has been associated with differential promoter activity and unfavourable ... -
Association of MMP3 but not TIMP2 gene variants with elite rugby player status and rugby code
Brazier, Jon; Antrobus, M; Herbert, A; Stebbings, G; Day, S; Heffernan, S; Erskine, R; Kilduff, L; Williams, A (2018-07-04)Introduction: Achilles tendon pathology and anterior cruciate ligament rupture are multifactorial conditions for which genetic risk factors have been identified. Single nucleotide polymorphisms (SNPs) within the MMP3 ... -
Bone Mineral Density and Associated Genetic Variants in High-level Caucasian Marathon Runners
Herbert, A; Williams, A; Lockey, S; Erskine, R; Sale, C; Hennis, P; Antrobus, M; Brazier, Jon; Heffernan, S; Day, S; Stebbings, G (2018-07-04)INTRODUCTION:Endurance runners (except those who may have low energy availability) tend to have higher total and/or loading site-specific bone mineral density (BMD) in comparison with non-athletes, most likely due to the ... -
Collagen gene polymorphisms previously associated with resistance to soft-tissue injury are more common in competitive runners than non-athletes
Dines, H; Nixon, J; Lockey, S; Herbert, A; Kipps, C; Pedlar, C; Day, S; Heffernan, S; Antrobus, M; Brazier, Jon; Erskine, R; Stebbings, G; Hall, E; Williams, A (2023-04-01)Single nucleotide polymorphisms (SNPs) of collagen genes have been associated with soft-tissue injury and running performance. However, their combined contribution to running performance is unknown. We investigated the ... -
Concussion-associated gene variant COMT rs4680 is associated with elite rugby athlete status
Antrobus, M; Brazier, Jon; Callus, P; Herbert, A; Stebbings, G; Day, S; Kilduff, L; Bennett, M; Erskine, R; Raleigh, Stuart; Collins, M.; Pitsiladis, Y; Heffernan, S; Williams, A (2023-09-01)Objective: Concussions are common match injuries in elite rugby and reports exist of reduced cognitive function and long-term health consequences that can interrupt or end a playing career and produce continued ill health. ... -
Concussion-associated gene variants and history of concussion in elite male rugby athletes
Antrobus, M; Brazier, Jon; Callus, P; Herbert, A; Stebbings, G; Martin, D.; Day, S; Kilduff, L; Bennett, M; Erskine, R; Raleigh, Stuart; Cullen, Tom; Collins, M.; Pitsiladis, Y; Heffernan, S; Williams, A (2024-07-05)Occurrence of and outcomes following a concussion are probably affected by the interaction of multiple genes in a polygenic manner [1,2]. This study investigated whether suspected concussion-associated polygenic profiles ... -
Gene Variants Previously Associated with Reduced Soft Tissue Injury Risk: Part 1 – Independent Associations with Elite Status in Rugby
Brazier, Jon; Antrobus, M; Herbert, A; Callus, P; Stebbings, G; Day, S; Heffernan, S; Kilduff, L; Bennett, M; Erskine, R; Raleigh, Stuart; Collins, M.; Pitsiladis, Y; Williams, A (2022-03-29)There is growing evidence of genetic contributions to tendon and ligament pathologies. Given the high incidence and severity of tendon and ligament injuries in elite rugby, we studied whether 13 gene polymorphisms previously ... -
Gene variants previously associated with reduced soft-tissue injury risk: Part 2 – Polygenic associations with elite status in Rugby
Brazier, Jon; Antrobus, M; Herbert, A; Callus, P; Khanal, P; Stebbings, G; Day, S; Heffernan, S; Kilduff, L; Bennett, M; Erskine, R; Raleigh, Stuart; Collins, M.; Pitsiladis, Y; Williams, Alun G. (2022-12-26)Part 1 of this genetic association series highlighted several genetic variants independently associated with elite status in rugby. However, it is highly likely that the genetic influence on elite status is polygenic due ... -
Genetic Factors That Could Affect Concussion Risk in Elite Rugby
Antrobus, M; Brazier, Jon; Stebbings, G; Day, S; Heffernan, S; Kilduff, L; Erskine, R; Williams, A (2021-01-22)Elite rugby league and union have some of the highest reported rates of concussion (mild traumatic brain injury) in professional sport due in part to their full-contact high-velocity collision-based nature. Currently, ... -
An Investigation into Genetic Associations with Musculoskeletal Soft Tissue Injuries in Elite Rugby – Preliminary Findings
Brazier, Jon; Antrobus, M; Heffernan, S; Stebbings, G; Day, S; Hennis, P; Erskine, R; Kilduff, L; Williams, A (2017-03-11) -
Tendon and Ligament Injuries in Elite Rugby: The Potential Genetic Influence
Brazier, Jon; Antrobus, M; Stebbings, G; Day, S; Heffernan, S; Cross, M; Williams, A (2019-06-04)This article reviews tendon and ligament injury incidence and severity within elite rugby union and rugby league. Furthermore, it discusses the biological makeup of tendons and ligaments and how genetic variation may ... -
Tendon and ligament-associated gene variants and history of soft tissue injury in elite male rugby athletes
Brazier, Jon; Antrobus, M; Callus, P; Herbert, A; Stebbings, G; Martin, D; Day, S; Kilduff, L; Bennett, M; Erskine, R; Raleigh, Stuart; Cullen, Tom; Collins, M.; Pitsiladis, Y; Heffernan, S; Williams, A (2024-07-05)There is a genetic component to tendon and ligament injuries which is highly likely to be polygenic in nature (1). Elite rugby has one of the highest reported injury incidences of any professional sport with some of the ... -
Tendon and Ligament-Related Genes Associate with Elite Status in Rugby
Brazier, Jon; Antrobus, M; Herbert, A; Stebbings, G; Day, S; Heffernan, S; Kilduff, L; Cullen, Tom; Raleigh, Stuart; Erskine, R; Williams, A (2020-10-28)INTRODUCTION: Elite rugby has one of the highest reported injury incidences of any professional sport (Brooks and Kemp, 2008). Some of the most severe injuries are those affecting tendon and ligament (Brazier et al., 2019), ...