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Browsing by Author "Hill, K."
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Characterisation of recombinant rat TRPM2 and a TRPM2-like conductance in cultured rat striatal neurons
Hill, K.; Tigue, N.; Kelsell, R.E.; Benham, C.D.; McNulty, S.; Schaefer, M.; Randall, A.D. (2006)TRPM2, a member of the TRP ion channel family, is expressed both in the brain and immune cells of the monocyte lineage. Functionally, it is unique in its activation by intracellular ADP-ribose and both oxidative and ... -
Flufenamic acid is a pH-dependent antagonist of TRPM2 channels
Hill, K.; Benham, C.D.; McNulty, S.; Randall, A.D. (2004)Like a number of other TRP channels, TRPM2 is a Ca2+-permeable non-selective cation channel, the activity of which is regulated by intracellular and extracellular Ca2+. A unique feature of TRPM2 is its activation by ... -
Hypofrontality in Schizophrenia. A meta-analysis of functional imaging studies
Hill, K.; Mann, L.; Laws, K.R.; Stephenson, C. M. E.; Nimmo-Smith, I.; McKenna, P. J. (2004)Objective: Hypofrontality is not a well-replicated finding in schizophrenia either at rest or under conditions of task activation. Method: Studies comparing whole brain and frontal blood flow/ metabolism in schizophrenic ... -
TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase
Fonfria, E.; Marshall, I.C.B.; Benham, C.D.; Boyfield, I.; Brown, J.D.; Hill, K.; Hughes, J.P.; Kelsell, R.E.; Skaper, S.D.; Scharenberg, A.M.; McNulty, S. (2004) -
TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated and functionally expressed in C13 microglia
Fonfria, E.; Mattei, C.; Hill, K.; Brown, J.T.; Randall, A.D.; Benham, C.D.; Skaper, S.D.; Campbell, C.A.; Crook, B.; Murdoch, P.R.; Wilson, J.M.; Murio, F.P.; Owen, D.; Tilling, P.L.; McNulty, S. (2006)We report the detailed expression profile of TRPM2 mRNA within the human central nervous system (CNS) and demonstrate increased TRPM2 mRNA expression at 1 and 4 weeks following ischemic injury in the rat transient middle ...