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Browsing by Author "Hitzel, L."
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Neighboring group participation of the indole nucleus : An unusual DAST-mediated rearrangerment reaction
Hallett, D.J.; Gerhard, U.; Goodacre, S.C.; Hitzel, L.; Sparey, T.J.; Thomas, S.; Rowley, M.; Ball, R.G. (2000-08-11)A rearrangement reaction involving the indole nucleus was investigated using stereochemical markers and low-temperature NMR experiments. Treatment of(3S,4S)-3-hydroxy-4-(2-phenyl-1H-indol-3-yl)-piperidine-1-carboxylic acid ... -
Synthesis and conformational dynamics of tricyclic pyridones containing a fused seven-membered ring
Gibson, K.R.; Hitzel, L.; Mortishire-Smith, R.J.; Gerhard, U.; Jelley, R.A.; Reeve, A.J.; Rowley, M.; Nadin, A.; Owens, A.P. (2002-12-27)A new synthetic approach to tricyclic pyridones bearing a fused seven-membered ring is described. These compounds exhibit atropisomerism and exist in enantiomeric forms. Chiral HPLC separation of the enantiomers has allowed ...