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Browsing by Author "Houston, J.B."
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Evaluation of recombinant cytochrome p450 enzymes as an in vitro system for metabolic clearance predictions
Stringer, R.A.; Strain-Damerell, C.; Nicklin, P.; Houston, J.B. (2009-05-01)The aim of this study was to explore the potential of recombinant cytochrome P450 (P450) enzymes for human metabolic clearance prediction. The relative abundance and relative activity approaches were compared as methods ... -
Reliability of human cryopreserved hepatocytes and liver microsomes as in vitro systems to predict metabolic clearance
Stringer, R.; Nicklin, P.L.; Houston, J.B. (2008-10-01)A total of 110 drugs, selected to cover a range of physicochemical and pharmacokinetic properties, were used to explore standard approaches to the prediction of in vivo metabolic clearance using drug-depletion profiles ...