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Browsing by Author "Husbands, Stephen M."
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BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates
Kiguchi, Norikazu; Ding, Huiping; Cami-Kobeci, Gerta; Sukhtankar, Devki D.; Czoty, Paul W.; DeLoid, Heather B.; Hsu, Fang Chi; Toll, Lawrence; Husbands, Stephen M.; Ko, Mei Chuan (2019-06-01)Background: The marked increase in mis-use of prescription opioids has greatly affected our society. One potential solution is to develop improved analgesics which have agonist action at both mu opioid peptide (MOP) and ... -
Synthesis, biological evaluation, and SAR studies of 14β-phenylacetyl substituted 17-cyclopropylmethyl-7, 8-dihydronoroxymorphinones derivatives : Ligands with mixed NOP and opioid receptor profile
Kumar, Vinod; Polgar, Willma E.; Cami-Kobeci, Gerta; Thomas, Mark P.; Khroyan, Taline V.; Toll, Lawrence; Husbands, Stephen M. (2018-09-19)A series of 14β-acyl substituted 17-cyclopropylmethyl-7,8-dihydronoroxymorphinone compounds has been synthesized and evaluated for affinity and efficacy for mu (MOP), kappa (KOP), and delta (DOP) opioid receptors and ...