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Browsing by Author "Huscroft, Grace S."
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Efficacy of novel antimicrobial agent SMT-19969 (SMT) against simulated Clostridium difficile infection in an in vitro human gut model
Baines, Simon D.; Freeman, J.; Huscroft, Grace S.; Todhunter, Sharie L.; Wilcox, M. H.; Vickers, R. (2011-09)Background: C. difficile infection (CDI) is the leading cause of nosocomial diarrhoea. Current CDI therapy is limited to metronidazole (M) or vancomycin. Recent evidence suggests reduced M efficacy and emergence of reduced ... -
Evaluation of linezolid for the treatment of Clostridium difficile infection caused by epidemic strains using an in vitro human gut model
Baines, Simon D.; Noel, Alan R.; Huscroft, Grace S.; Todhunter, Sharie L.; O'Connor, Rachael; Hobbs, Joanne K.; Freeman, Jane; Lovering, Andy M.; Wilcox, M. H. (2011)Therapeutic options in Clostridium difficile infection (CDI) are limited. We examined linezolid activity in vitro and potential therapeutic efficacy using a gut model of CDI. -
Nitazoxanide is active against Clostridium difficile strains with reduced susceptibility to metronidazole
Freeman, Jane; Baines, Simon D.; Todhunter, Sharie L.; Huscroft, Grace S.; Wilcox, M. H. (2011)Treatment strategies for Clostridium difficile infection (CDI) have changed little over the past two decades. Metronidazole and vancomycin continue to be the first-line antimicrobial treatments for CDI.1 While the drugs ...