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Browsing by Author "Inal, Jameel M."
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Decoy ACE2-expressing extracellular vesicles that competitively bind SARS-CoV-2 as a possible COVID-19 therapy
Inal, Jameel M. (2020-06-16)The novel strain of coronavirus that appeared in 2019, SARS-CoV-2, is the causative agent of severe respiratory disease, COVID-19, and the ongoing pandemic. As for SARS-CoV that caused the SARS 2003 epidemic, the receptor ... -
Exosomes serve as tumour markers for personalized diagnostics owing to their important role in cancer metastasis
An, Taixue; Qin, Sihua; Xu, Yong; Tang, Yueting; Huang, Yiyao; Situ, Bo; Inal, Jameel M.; Zheng, Lei (2015-06-22)Exosomes, membrane vesicles of 40-100 nm in diameter, are derived from endosomes in various cells. The bioactive molecules specifically packed into exosomes can be horizontally transferred into recipient cells changing ... -
A novel role for peptidylarginine deiminases in microvesicle release reveals therapeutic potential of PAD inhibition in sensitizing prostate cancer cells to chemotherapy
Kholia, Sharad; Jorfi, Samireh; Thompson, Paul R.; Causey, Corey P.; Nicholas, Anthony P.; Inal, Jameel M.; Lange, Sigrun (2015-06-22)Introduction: Protein deimination, defined as the post-translational conversion of protein-bound arginine to citrulline, is carried out by a family of 5 calcium-dependent enzymes, the peptidylarginine deiminases (PADs) and ... -
A Pilot Study on Peptidylarginine Deiminases and Protein Deimination in Animal Cancers across Vertebrate Species
Inal, Jameel M.; Hristova, Mariya; Lange, Sigrun (2022-08-04)PADs are a group of calcium-dependent enzymes that play key roles in inflammatory pathologies and have diverse roles in cancers. PADs cause irreversible post-translational modification of arginine to citrulline, leading ...