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Browsing by Author "Iravani, Mahmoud"
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Alpha7 nicotinic receptor- mediated reduction of L-DOPA-induced dyskinesia in 6OHDA rat model of Parkinson’s Disease
Malekizadeh, Yasaman; Hassankhani, Kiana; Kingslake, Alice; Annett, Lucy; Shoaib, Mohammed; Iravani, Mahmoud (SAGE Publications, 2023-04-26)Introduction: In Parkinson’s Disease (PD) induction of involuntary movements (AIMs) or dyskinesia, after long-term L-DOPA therapy is a major problem. Evidence shows that nicotine can protect against nigrostriatal damage ... -
Altered detrusor contractility in MPTP-treated common marmosets with bladder hyperreflexia
Pritchard, Sara; Hikima, Atsuko; Jackson, Michael; Lione, Lisa; Benham, Christopher; Chaudhuri, K. Ray; Rose, Sarah; Jenner, Peter; Iravani, Mahmoud (2017-05-17)Bladder hyperreflexia is a common non-motor feature of Parkinson’s disease. We now report on the contractility of the isolated primate detrusor strips devoid of nerve input and show that following MPTP, the amplitude and ... -
Arylalkylpiperazines for use as neuroprotective agents : Arlyalkylpiperazines and neuroprotection
Basic and Clinical Science Unit; School of Life and Medical Sciences; Centre for Health Services and Clinical Research; Centre for Research in Mechanisms of Disease and Drug Discovery; Department of Clinical, Pharmaceutical and Biological Science; Iravani, Mahmoud (2016-04-07)A compound of the general formula A or a or a pharmaceutically acceptable salt or solvate thereof, wherein: R1 is selected from the group consisting of: C1-C12-alkyl, C3-C12-cycloalkyl, C6- C10-aryl, and C5-C7-heteroaryl; ... -
Contractile dysfunction and nitrergic dysregulation in small intestine of a primate model of Parkinson’s disease : contractile dysfunction in MPTP-treated primate ileum
Coletto, E; Dolan, John S; Pritchard, Sara; Gant, Alex; Hikima, Atsuko; Jackson, Michael J; Benham, Christopher; Chaudhuri, K. Ray; Rose, Sarah; Jenner, Peter; Iravani, Mahmoud (2019-06-10)Bowel dysfunction is a common non-motor symptom in Parkinson's disease (PD). The main contractile neurotransmitter in the GI tract is acetylcholine (ACh), while nitric oxide (NO) causes the relaxation of smooth muscle in ... -
Dysregulation of epithelial ion transport and neurochemical changes in the colon of a parkinsonian primate
Coletto, Erika; Tough, Ian; Pritchard, Sara; Hikima, Atsuko; Jackson, Michael; Jenner, Peter; Chaudhuri, K. Ray; Cox, Helen; Iravani, Mahmoud; Rose, Sarah (2021-01-21)The pathological changes underlying gastrointestinal (GI) dysfunction in Parkinson’s disease (PD) are poorly understood and the symptoms remain inadequately treated. In this study we compared the functional and neurochemical ... -
The neuroprotective properties of NLX-112 in MPTP treated mice are mediated by reactive gliosis and astrocytic GDNF
Powell, William; Depoortere, Ronan; Annett, Lucy; Newman-Tancredi, Adrian; Iravani, Mahmoud (SAGE Publications, 2023-05-30)Introduction: Preventing dopaminergic (DA) neuronal death is key to halting the progression of Parkinson’s Disease (PD). There is evidence for serotonin 5-HT1A agonists having neuroprotective effects on DA neurons. NLX-112 ...