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Browsing by Author "Iravani, Mahmoud M."
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3,4-methylenedioxymethamphetamine (ecstasy) inhibits dyskinesia expression and normalizes motor activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates
Iravani, Mahmoud M.; Jackson, M. J.; Kuoppamaki, M.; Smith, L. A.; Jenner, P. (2003-10-08)Ecstasy [3,4-methylenedioxymethamphetamine (MDMA)] was shown to prolong the action of L-3,4-dihydroxyphenylalanine (L-DOPA) while suppressing dyskinesia in a single patient with Parkinson's disease (PD). The clinical basis ... -
3-Nitrotyrosine-dependent dopaminergic neurotoxicity following direct nigral administration of a peroxynitrite but not a nitric oxide donor
Iravani, Mahmoud M.; Haddon, C. O.; Rose, S.; Jenner, P. (2006-01-05)The presence of 3-nitrotyrosine (3-NT) adducts in Lewy bodies in Parkinson's disease suggests a role for nitrative stress in dopaminergic cell death. Whether this is a direct effect of increased nitric oxide (NO) formation ... -
The acute and the long-term effects of nigral lipopolysaccharide administration on dopaminergic dysfunction and glial cell activation
Iravani, Mahmoud M.; Leung, Clement C. M.; Sadeghian, Mona; Haddon, C. O.; Rose, Sarah; Jenner, P. (2005-07)Sustained reactive microgliosis may contribute to the progressive degeneration of nigral dopaminergic neurons in Parkinson's disease (PD), in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exposed human and in non-human ... -
Age-associated changes in protein oxidation and proteasome activities in rat brain: Modulation by antioxidants
El Mohsen, M. M. A.; Iravani, Mahmoud M.; Spencer, J. P. E.; Rose, S.; Fahim, A. T.; Motawi, T. M. K.; Ismail, N. A. F.; Jenner, P. (2005-10-21)The free radical theory of ageing postulates that age-associated neurodegeneration is caused by an imbalance between pro-oxidants and antioxidants resulting in oxidative stress. The current study showed regional variation ... -
Behavioural and immunohistochemical changes following supranigral administration of sonic hedgehog in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmosets
Dass, B.; Iravani, Mahmoud M.; Jackson, M. J.; Engber, T. M.; Galdes, A.; Jenner, P. (2002)Sonic hedgehog (SHH) has trophic actions on dopaminergic cell cultures and protects them from MPP+ toxicity but its in vivo actions have not been explored. We now investigate the effects of unilateral supranigral administration ... -
Comparison of somatodendritic and axon terminal dopamine release in the ventral tegmental area and the nucleus accumbens
Iravani, Mahmoud M.; Muscat, R.; Kruk, Z. L. (1996-02)Fast cyclic voltammetry at a carbon fibre microelectrode was used to measure dopamine release following electrical or chemical stimulation in rat brain slices incorporating either the ventral tegmental area or the core ... -
Continuous administration of rotigotine to MPTP-treated common marmosets enhances anti-parkinsonian activity and reduces dyskinesia induction
Stockwell, K. A.; Scheller, D.; Rose, S.; Jackson, M. J.; Tayarani-Binazir, K.; Iravani, Mahmoud M.; Smith, L. A.; Olanow, C. W.; Jenner, P. (2009-10)Rotigotine is a novel, non-ergoline dopamine D-3/D-2/D-1-receptor agonist for the treatment of Parkinson's disease that can be Continuously delivered by the transdermal route to provide stable plasma levels. Continuous ... -
Continuous delivery of ropinirole reverses motor deficits without dyskinesia induction in MPTP-treated common marmosets
Stockwell, K. A.; Virley, D. J.; Perren, M.; Iravani, Mahmoud M.; Jackson, M. J.; Rose, S.; Jenner, P. (2008-05)L-DOPA treatment of Parkinson's disease induces a high incidence of motor complications, notably dyskinesia. Longer acting dopamine agonists, e.g. ropinirole, are thought to produce more continuous dopaminergic stimulation ... -
Continuous rotigotine administration reduces dyskinesia resulting from pulsatile treatment with rotigotine or L-DOPA in MPTP-treated common marmosets
Stockwell, K. A.; Scheller, D. K. A.; Smith, L. A.; Rose, S.; Iravani, Mahmoud M.; Jackson, M. J.; Jenner, P. (2010-01)We previously showed that continuous infusion of rotigotine resulted in less dyskinesia than repeated pulsatile rotigotine administration or repeated oral administration Of L-DOPA in MPTP-treated marmosets. Now we investigate ... -
Continuous subcutaneous infusion of pramipexole protects against lipopolysaccharide-induced dopaminergic cell death without affecting the inflammatory response
Iravani, Mahmoud M.; Sadeghian, Mona; Leung, Clement C. M.; Tel, Banu C.; Rose, Sarah; Schapira, Anthony H.; Jenner, Peter (2008-08)The D2/D3 dopamine receptor agonist pramipexole, protects against toxin-induced dopaminergic neuronal destruction but its mechanism of action is unknown. Inflammation following glial cell activation contributes to cell ... -
Continuous vs pulsatile administration of rotigotine in rat and monkey models of Parkinson's disease: A comparison
Scheller, D. K. A.; Schmidt, W. J.; Jackson, M. J.; Ruess, U.; Stockwell, K.; Heindl, M.; Iravani, Mahmoud M.; Tayarani-Binazir, K.; Rose, S.; Jenner, P. (2008) -
Differential release of dopamine by nitric oxide in subregions of rat caudate putamen slices
Iravani, Mahmoud M.; Millar, J.; Kruk, Z. L. (1998-11)Fast cyclic voltammetry was used to measure NO and dopamine (DA) simultaneously in rat caudate putamen (CPu) slices. Analysis of electrochemical signals obtained from mixtures of DA and NO showed that subtraction of either ... -
Differential sensitivities of rat striatal D-2 Dopamine autoreceptor sites
Iravani, Mahmoud M.; Kruk, Z. L. (1992-10) -
Differential-effects of Nifedipine on nerve-mediated and noradrenaline-evoked contractions of rat anococcygeus muscle
Iravani, Mahmoud M.; Zar, M. A. (1993-11-30)In rat anococcygeus muscle the inhibitory effect of nifedipine (0.01. 0.1, 1.0 and 10 muM) was determined on adrenergic twitches in response to electrical field stimulation (trains of 4 pulses, 0.1 ms pulse duration. 10 ... -
Direct effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin or dopamine release and uptake in the caudate putamen, nucleus accumbens, substantia nigra pars reticulate, and the dorsal raphe nucleus slices
Iravani, Mahmoud M.; Asari, D.; Patel, J.; Wieczorek, W. J.; Kruk, Z. L. (2000-06-15)We examined the effects of pressure ejected 3,4-methylenedioxymethamphetamine (MDMA) from a micropipette on direct chemically stimulated release, and on electrically stimulated serotonin (5-HT) or dopamine (DA) release in ... -
Dopamine releasing actions of NMDA in rat caudate putamen studied by fast cyclic voltammetry
Iravani, Mahmoud M.; Kruk, Z. L. (1992-07)Investigations in vitro (Clow & Jhamandas, 1989; Krebs et al., 1990) have shown that glutamic acid, acting at NMDA receptors in the absence of Mg2+ can stimulate the release of dopamine (DA) from nerve terminals in the rat ... -
Ecstasy (3,4-Methylenedioxymethamphetamine) inhibits dyskinesia expression and normalises locomotor activity in parkinsonian primates
Iravani, Mahmoud M.; Jackson, M. J.; Al-Barghouthy, G.; Kouppamaki, M.; Jenner, P. (2002) -
The effect of exercise and heart rate on fibrinolytic activity
Dewar, H. A.; Zar, M. A.; Smith, N. M.; Iravani, Mahmoud M.; Stappenbeck, R. (1993-06) -
Effect of frequency of stimulation on neurogenic responses of isolated rat epidymal vas deferens
Iravani, Mahmoud M.; Zar, M. A. (1987-12) -
Effect of Nifedipine on the contractile responses of the isolated rat bladder
Zar, M. A.; Iravani, Mahmoud M.; Luheshi, G. N. (1990-04)