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Browsing by Author "Jia, H."
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Association of the Gsα Gene With Essential Hypertension and Response to ß-Blockade
Jia, H.; Hingorani, A.D.; Sharma, P.; Hopper, R.; Dickerson, Claire; Trutwein, D.; Lloyd, D.D.; Brown, M.J. (1999)We examined whether the GNAS1 locus, encoding the Gs protein α-subunit (Gsα), is implicated in the genetic causes of essential hypertension. A common silent polymorphism (ATTATC, Ile131) was identified in exon 5 of the Gsα ... -
[beta]2-Adrenoceptor gene polymorphisms and blood pressure variations in East Anglian Caucasians
Jia, H.; Sharma, P.; Hopper, R.; Dickerson, Claire; Lloyd, D.D.; Brown, M.J. (2000)Objective: The amino-terminal polymorphisms, Arg16Gly and Gln27Glu, of the [beta]2-adrenergic receptor ([beta]2AR) have been shown to affect regulation of the receptor expression by an agonist in cell culture studies. The ... -
Renin-angiotensin system gene polymorphisms influence blood pressure and the response to angiotensin converting enzyme inhibition
Hingorani, A.D.; Stevens, P.; Brown, M.J.; Jia, H.; Hopper, R.; Dickerson, Claire (1995)Objectives: To investigate the relationship between polymorphisms in the angiotensin converting enzyme (ACE), angiotensinogen (AGT) and type 1 angiotensin-II (AT1R) genes and (1) quantitative variations in blood pressure ...