- UHRA Home
- Browsing by Author
Browsing by Author "Kanji, Rahim"
Now showing items 1-13 of 13
-
Angiotensin Converting Enzyme 2 may mediate disease severity in COVID-19
Gue, Ying X.; Kanji, Rahim; Gorog, Diana (2020-06-09)Identification of vulnerability to severe coronavirus disease 2019 (COVID-19) is extremely important and might allow optimised shielding and easing of lockdown. The disease is attributed to the severe acute respiratory ... -
Biomarkers of Thrombotic Status Predict Spontaneous Reperfusion in Patients With ST-Segment Elevation Myocardial Infarction
Kanji, Rahim; Gue, Ying X.; Memtsas, Vassilios; Spencer, Neil H.; Gorog, Diana (2023-05-16)Background Spontaneous reperfusion, seen in ∼20% of patients with ST-segment elevation myocardial infarction (STEMI), manifests as normal epicardial flow in the infarct-related artery, with or without ST-segment resolution, ... -
Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction
Kanji, Rahim; Gue, Ying X.; Farag, Mohamed F.; Spencer, Neil H.; Mutch, Nicola J.; Gorog, Diana A. (2022-11-14)Hypofibrinolysis is a recently-recognized risk factor for recurrent cardiovascular events in patients with ST-segment elevation myocardial infarction (STEMI), but the mechanistic determinants of this are not well understood. ... -
Development of a novel risk score to predict mortality in patients admitted to hospital with COVID-19
Gue, Ying X.; Tennyson, Maria; Gao, Jovia; Ren, Shuhui; Kanji, Rahim; Gorog, Diana A. (2020-12-07)Patients hospitalised with COVID-19 have a high mortality. Identification of patients at increased risk of adverse outcome would be important, to allow closer observation and earlier medical intervention for those at risk, ... -
Endogenous fibrinolysis - relevance to clinical thrombosis risk assessment
Kanji, Rahim; Kubica, Jacek; Navarese, Eliano P; Gorog, Diana (2020-12-09)The development of an obstructive luminal thrombus is pathological and considered a failure of endogenous fibrinolysis. The consequences may be fatal, or result in lasting downstream organ damage. Therefore, assessment of ... -
Fibrinolysis in platelet thrombi
Kanji, Rahim; Gue, Ying X.; Memtsas, Vassilios; Gorog, Diana (2021-05-12)The extent and duration of occlusive thrombus formation following an arterial atherothrombotic plaque disruption may be determined by the effectiveness of endogenous fibrinolysis. The determinants of endogenous fibrinolysis ... -
Measuring thrombus stability at high shear, together with thrombus formation and endogenous fibrinolysis: first experience using the Global Thrombosis Test 3 (GTT-3)
Kanji, Rahim; Leader, Joshua; Memtsas, Vassilios; Gorog, Diana (2023-08-07)Thrombus formation in a severely stenosed artery is initiated by high shear activation of platelets, with soluble platelet agonists, such as ADP and thromboxane, playing only a secondary role in the growth and stability ... -
MINOCA presenting with STEMI- a review of incidence, aetiology, assessment and treatment
Gue, Ying X.; Kanji, Rahim; Gati, Sabiha; Gorog, Diana (2020-04-30)Myocardial infarction with non-obstructive coronary artery (MINOCA) is a condition previously thought to be benign but has recently been shown to have comparable mortality to that of acute coronary syndrome with obstructive ... -
Optimal tests to minimise bleeding and ischaemic complications in patients on extracorporeal membrane oxygenation
Kanji, Rahim; Vandenbriele, Christophe; Arachchillage, Deepa R.J; Price, Susanna; Gorog, Diana (2021-05-13)Patients supported with extracorporeal membrane oxygenation (ECMO) experience a very high frequency of bleeding and ischaemic complications, including stroke and systemic embolism. These patients require systemic ... -
Rationale and design of "Can Very Low Dose Rivaroxaban (VLDR) in addition to dual antiplatelet therapy improve thrombotic status in acute coronary syndrome (VaLiDate-R)" study : A randomised trial modulating endogenous fibrinolysis in patients with acute coronary syndrome
Gue, Ying X; Kanji, Rahim; Wellsted, David M; Srinivasan, Manivannan; Wyatt, Solange; Gorog, Diana A (2019-12-23)Impaired endogenous fibrinolysis is novel biomarker that can identify patients with ACS at increased cardiovascular risk. The addition of Very Low Dose Rivaroxaban (VLDR) to dual antiplatelet therapy has been shown to ... -
Spontaneous Reperfusion in STEMI: its mechanisms and possible modulation
Leader, Joshua; Kanji, Rahim; Gorog, Diana (2024-03-12)Patients with transient ST-segment elevation myocardial infarction or spontaneous reperfusion, which occurs in approximately 20% of patients with ST-segment elevation myocardial infarction (STEMI), have smaller infarcts ... -
Thrombotic complications in 2,928 patients with COVID-19 treated in intensive care: a systematic review
Jenner, William; Kanji, Rahim; Mirsadraee, Saeed; Gue, Ying X.; Price, Susanna; Prasad, Sanjay; Gorog, Diana (2021-04-01)A prothrombotic state is reported with severe COVID-19 infection, which can manifest in venous and arterial thrombotic events. Coagulopathy is reflective of more severe disease and anticoagulant thromboprophylaxis is ... -
Usefulness of the NULL-PLEASE Score to predict 1 survival in out-of hospital cardiac arrest
Gue, Ying; Sayers, Max; Whitby, Benjamin; Kanji, Rahim; Adatia, Krishma; Smith, Robert; Davies, William; Perperoglou, Aris; Potpara, Tatjana; Lip, Gregory Y H; Gorog, Diana (2020-05-07)Purpose: Out-of-hospital cardiac arrest (OHCA) carries a very high mortality even after successful cardiopulmonary resuscitation. Currently, information given to relatives regarding prognosis following resuscitation is ...