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Browsing by Author "Karu, Kersti"
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Induction of the cytoprotective enzyme heme oxygenase-1 by statins is enhanced in vascular endothelium exposed to laminar shear stress and impaired by disturbed flow
Ali, Faisal; Zakkar, Mustafa; Karu, Kersti; Lidington, Elaine A.; Hamdulay, Shahir S.; Boyle, Joseph J.; Zloh, Mire; Bauer, Andrea; Haskard, Dorian O; Evans, Paul C.; Mason, Justin C. (2009-07)In addition to cholesterol-lowering properties, statins exhibit lipid-independent immunomodulatory, anti-inflammatory actions. However, high concentrations are typically required to induce these effects in vitro, raising ... -
Relative quantification of polyethylene glycol 400 excreted in the urine of male and female volunteers by direct injection electrospray-selected ion monitoring mass spectrometry
Ashiru, Diane A. I.; Karu, Kersti; Zloh, Mire; Patel, Rajesh; Basit, Abdul W. (2011)The use of polyethylene glycol 400 (PEG 400) as an excipient in oral formulations can have profound and differing effects on drug bioavailability in men and women; therefore an understanding of the pharmacokinetics of this ...