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Browsing by Author "Kendall, Sharon"
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Molecular basis for DarT ADP-ribosylation of a DNA base
Schuller, Marion; Butler, Rachel; Ariza, Antonio; Tromans-Coia, Callum; Jankevicius, Gytis; Claridge, Tim; Kendall, Sharon; Goh, Shan; Stewart, Graham; Ahel, Ivan (2021-08-26)ADP-ribosyltransferases use NAD+ to catalyse substrate ADP-ribosylation1, and thereby regulate cellular pathways or contribute to toxin-mediated pathogenicity of bacteria2–4. Reversible ADP-ribosylation has traditionally ... -
Re-sensitization of Mycobacterium smegmatis to Rifampicin Using CRISPR Interference Demonstrates Its Utility for the Study of Non-essential Drug Resistance Traits
Faulkner, Valwynne; Cox, Adrienne; Goh, Shan; van Bohemen, Annelies; Gibson, Amanda; Liebster, Oliver; Wren, Brendan; Willcocks, Sam; Kendall, Sharon (2021-02-01)A greater understanding of the genes involved in antibiotic resistance in Mycobacterium tuberculosis (Mtb) is necessary for the design of improved therapies. Clustered regularly interspaced short palindromic repeat ...