Browsing by Author "Khengar, Rajeshree H."

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    • Free radical facilitated damage of ungual keratin 

      Khengar, Rajeshree H.; Brown, Marc; Turner, Rob B.; Traynor, M.J.; Holt, Katherine B.; Jones, Stuart A. (2010-09-01)
      Thioglycolic acid (TA) and urea hydrogen peroxide (urea H2O2) are thought to disrupt alpha-keratin disulfide links in the nail However, optimal clinical use of these agents to improve the treatment of nail disorders is ...

    • Overcoming the nail barrier : A systematic investigation of ungual chemical penetration enhancement 

      Brown, Marc; Khengar, Rajeshree H.; Turner, Rob B.; Forbes, B.; Traynor, M.J.; Evans, C.R.G.; Jones, S. A. (2009-03-31)
      This study investigated the in vitro nail permeability of penetrants of varying lipophilicity—caffeine (CF, log P −0.07), methylparaben (MP, log P 1.96) and terbinafine (TBF, log P 3.3) and the effect of 2 novel penetration ...

    • Topical corticosteroid delivery into human skin using hydrofluoroalkane metered dose aerosol sprays 

      Reid, M.L.; Benaouda, F.; Khengar, Rajeshree H.; Jones, S.A.; Brown, Marc (2013-08-16)
      Drug loaded hydrofluoroalkane (HFA) sprays can generate effective pharmaceutical formulations, but a deeper understanding of the manner in which these dynamic systems drive the process of in situ semi-solid dosage form ...