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Browsing by Author "Kim, Sarah"
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Single copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic neurodegeneration
Baskoylu, Saba N; Yersak, Jill; O'Hern, Patrick; Grosser, Sarah; Simon, Jonah; Kim, Sarah; Schuch, Kelsey; Dimitriadi, Maria; Yanagi, Katherine S; Lins, Jeremy; Hart, Anne C (2018-10-08)Mutations in Cu/Zn superoxide dismutase 1 (SOD1) lead to Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease that disproportionately affects glutamatergic and cholinergic motor neurons. Previous work with SOD1 ...