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Browsing by Author "Kioko, Mwikali"
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Extracellular vesicles could be a putative posttranscriptional regulatory mechanism that shapes intracellular RNA levels in Plasmodium falciparum
Kioko, Mwikali; Pance, Alena; Mwangi, Shaban; Goulding, David; Kemp, Alison; Rono, Martin; Ochola-Oyier, Lynette Isabella; Bull, Pete C.; Bejon, Philip; Rayner, Julian C.; Abdi, Abdirahman I. (2023-10-13)Plasmodium falciparum secretes extracellular vesicles (PfEVs) that contain parasite-derived RNA. However, the significance of the secreted RNA remains unexplored. Here, we compare secreted and intracellular RNA from asexual ... -
The mRNA content of plasma extracellular vesicles provides a window into molecular processes in the brain during cerebral malaria
Kioko, Mwikali; Mwangi, Shaban; Pance, Alena; Ochola-Oyier, Lynette Isabella; Kariuki, Symon; Newton, Charles; Bejon, Philip; Rayner, Julian C; Abdi, Abdirahman I (2024-08-16)The impact of cerebral malaria on the transcriptional profiles of cerebral tissues is difficult to study using noninvasive approaches. We isolated plasma extracellular vesicles (EVs) from patients with cerebral malaria and ...