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Browsing by Author "Kirkby, N.S."
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Contribution of COX1 and COX2 to prostacyclin release by healthy mouse tissues
Kirkby, N.S.; Harrington, Louise; Lundberg, Martina; Hoefer, T.; Warner, Tim D.; Mitchell, Jane A. (2011-06) -
Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system
Kirkby, N.S.; Lundberg, M.H.; Harrington, L.S.; Leadbeater, P.D.M.; Potter, C.M.F.; Al-Yamani, M.; Adeyemi, O.; Mitchell, J.A.; Warner, T.D.; Milne, G.L. (2012-10-23)Prostacyclin is an antithrombotic hormone produced by the endothelium, whose production is dependent on cyclooxygenase (COX) enzymes of which two isoforms exist. It is widely believed that COX-2 drives prostacyclin production ... -
LC-MS/MS Confirms That COX-1 Drives Vascular Prostacyclin Whilst Gene Expression Pattern Reveals Non-Vascular Sites of COX-2 Expression
Kirkby, N.S.; Zaiss, A.K.; Urquhart, P.; Jiao, J.; Austin, P.J.; Al-Yamani, Malak; Lundberg, M.H.; MacKenzie, Louise; Warner, T.D.; Nicolaou, A.; Herschman, H.R.; Mitchell, J.A. (2013-07-09)There are two schools of thought regarding the cyclooxygenase (COX) isoform active in the vasculature. Using urinary prostacyclin markers some groups have proposed that vascular COX-2 drives prostacyclin release. In contrast, ... -
Nitric oxide-dependent vasodilation is compromised in isolated pulmonary arteries from COX knockout mice
Wright, Will; MacKenzie, Louise Susan; Kirkby, N.S.; Mitchell, Jane A. (2013-04)Cyclooxygenase (COX) has two isoforms and is essential for prostanoid synthesis. COX-1 is constitutive whilst COX-2 is induced in inflammation. Two COX products, prostacyclin (PGI2) and thromboxane (TxA2), regulate vessel ... -
Role of the endothelium and COX-1 in prostacyclin generation by whole vessels stimulated with different agonists
Alyamanil, Malak; Kirkby, N.S.; MacKenzie, Louise Susan; Lundberg, M.H.; Warner, T.D.; Mitchell, J.A. (2012)Prostacyclin is an important cardioprotective hormone produced by the vascular wall, whose synthesis is dependent on cyclo-oxygenase (COX) enzymes. In healthy vessels the endothelium is thought to be the main site of ...