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Browsing by Author "Kirkby, Nicholas S."
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Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine : novel explanation of cardiovascular side effects associated with anti-inflammatory drugs
Ahmetaj-Shala, Blerina; Kirkby, Nicholas S.; Knowles, Rebecca; Al'Yamani, Malak; Mazi, Sarah; Wang, Zhen; Tucker, Arthur T.; Mackenzie, Louise; Armstrong, Paul C. J.; Nüsing, Rolf M.; Tomlinson, James A. P.; Warner, Timothy D.; Leiper, James; Mitchell, Jane A. (2015-02-17)BACKGROUND: Cardiovascular side effects associated with cyclooxygenase-2 inhibitor drugs dominate clinical concern. Cyclooxygenase-2 is expressed in the renal medulla where inhibition causes fluid retention and increased ... -
A New NO-Releasing Nanoformulation for the Treatment of Pulmonary Arterial Hypertension
Mohamed, Nura A.; Ahmetaj-Shala, Blerina; Duluc, Lucie; Mackenzie, Louise S.; Kirkby, Nicholas S.; Reed, Daniel M.; Lickiss, Paul D.; Davies, Robert P.; Freeman, Gemma R.; Wojciak-Stothard, Beata; Chester, Adrian H.; El-Sherbiny, Ibrahim M.; Mitchell, Jane A.; Yacoub, Magdi H. (2016-04)Pulmonary arterial hypertension (PAH) is a chronic and progressive disease which continues to carry an unacceptably high mortality and morbidity. The nitric oxide (NO) pathway has been implicated in the pathophysiology and ... -
Reply to Letter Regarding Article, "Evidence That Links Loss of Cyclooxygenase-2 With Increased Asymmetric Dimethylarginine : Novel Explanation of Cardiovascular Side Effects Associated With Anti-Inflammatory Drugs"
Ahmetaj-Shala, Blerina; Kirkby, Nicholas S.; Knowles, Rebecca; Al'Yamani, Malak; Mazi, Sara; Wang, Zhen; Tucker, Arthur T.; Mackenzie, Louise Susan; Armstrong, Paul C. J.; Nüsing, Rolf M.; Tomlinson, James A. P.; Warner, Timothy D.; Leiper, James; Mitchell, Jane A. (2015-10-27)