- UHRA Home
- Browsing by Author
Browsing by Author "Knudsen, Jakob G"
Now showing items 1-2 of 2
-
Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production
Knudsen, Jakob G; Hamilton, Alexander; Ramracheya, Reshma; Tarasov, Andrei I; Brereton, Melissa; Haythorne, Elizabeth; Chibalina, Margarita V; Spégel, Peter; Mulder, Hindrik; Zhang, Quan; Ashcroft, Frances M; Adam, Julie; Rorsman, Patrik (2019-02-05)Diabetes is a bihormonal disorder resulting from combined insulin and glucagon secretion defects. Mice lacking fumarase (Fh1) in their β cells (Fh1βKO mice) develop progressive hyperglycemia and dysregulated glucagon ... -
Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion
Vergari, Elisa; Knudsen, Jakob G; Ramracheya, Reshma; Salehi, Albert; Zhang, Quan; Adam, Julie; Asterholm, Ingrid Wernstedt; Benrick, Anna; Briant, Linford J B; Chibalina, Margarita V; Gribble, Fiona M; Hamilton, Alexander; Hastoy, Benoit; Reimann, Frank; Rorsman, Nils J G; Spiliotis, Ioannis I; Tarasov, Andrei; Wu, Yanling; Ashcroft, Frances M; Rorsman, Patrik (2019-01-11)Hypoglycaemia (low plasma glucose) is a serious and potentially fatal complication of insulin-treated diabetes. In healthy individuals, hypoglycaemia triggers glucagon secretion, which restores normal plasma glucose levels ...