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Browsing by Author "Kosgodage, Uchini S"
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Cannabidiol (CBD) is a novel inhibitor for exosome and microvesicle (EMV) release in cancer
Kosgodage, Uchini S; Mould, Rhys; Henley, Aine; Nunn, alistair; Guy, Geoffrey; Thomas, E. Louise; Inal, Jameel; Bell, Jimmy; Lange, Sigrun (2018-08-13)Exosomes and microvesicles (EMV) are lipid bilayer-enclosed structures, released by cells and involved in intercellular communication through transfer of proteins and genetic material. EMV release is also associated with ... -
Cannabidiol Affects Extracellular Vesicle Release, miR21 and miR126, and Reduces Prohibitin Protein in Glioblastoma Multiforme Cells
Kosgodage, Uchini S; Uysal-Onganer, Pinar; MacLatchy, Amy; Mould, Rhys; Nunn, Alistair; Guy, Geoffrey; Kraev, Igor; Chatterton, Nicholas; Inal, Jameel; Thomas, E. Louise; Bell, Jimmy; Lange, Sigrun (2019-03-01)Glioblastoma multiforme (GBM) is the most common and aggressive form of primary malignant brain tumor in adults, with poor prognosis. Extracellular vesicles (EVs) are key-mediators for cellular communication through transfer ... -
Cannabidiol Is a Novel Modulator of Bacterial Membrane Vesicles
Kosgodage, Uchini S; Matewele, Paul; Awamaria, Brigitte; Kraev, Igor; Warde, Purva; Mastroianni, Giulia; Nunn, alistair; Guy, Geoffrey; Bell, Jimmy; Inal, Jameel; Lange, Sigrun (2019-09-10)Membrane vesicles (MVs) released from bacteria participate in cell communication and host-pathogen interactions. Roles for MVs in antibiotic resistance are gaining increased attention and in this study we investigated if ... -
Chloramidine/Bisindolylmaleimide-I-Mediated Inhibition of Exosome and Microvesicle Release and Enhanced Efficacy of Cancer Chemotherapy
Kosgodage, Uchini S; Trindade, Rita P; Thompson, Paul R; Inal, Jameel M; Lange, Sigrun (2017-05-09)Microvesicle (MV) release from tumour cells influences drug retention, contributing to cancer drug resistance. Strategically regulating MV release may increase drug retention within cancer cells and allow for lower doses ... -
Peptidylarginine deiminase inhibitors reduce bacterial membrane vesicle release and sensitize bacteria to antibiotic treatment
Kosgodage, Uchini S; Matewele, Paul; Mastroianni, Giulia; Lange, Sigrun; Kraev, Igor; Brotherton, Dominik; Awamaria, Brigitte; Nicholas, Anthony P.; Inal, Jameel (2019-06-27)Outer membrane and membrane vesicles (OMV/MV) are released from bacteria and participate in cell communication, biofilm formation and host-pathogen interactions. Peptidylarginine deiminases (PADs) are phylogenetically ... -
Peptidylarginine Deiminases Post-Translationally Deiminate Prohibitin and Modulate Extracellular Vesicle Release and MicroRNAs in Glioblastoma Multiforme
Kosgodage, Uchini S; Uysal-Onganer, Pinar; MacLatchy, Amy; Kraev, Igor; Chatterton, Nicholas; Nicholas, Anthony P.; Inal, Jameel; Lange, Sigrun (2018-12-28)Glioblastoma multiforme (GBM) is the most aggressive form of adult primary malignant brain tumour with poor prognosis. Extracellular vesicles (EVs) are a key-mediator through which GBM cells promote a pro-oncogenic ... -
Peptidylarginine Deiminases-Roles in Cancer and Neurodegeneration and Possible Avenues for Therapeutic Intervention via Modulation of Exosome and Microvesicle (EMV) Release?
Lange, Sigrun; Gallagher, Mark; Kholia, Sharad; Kosgodage, Uchini S; Hristova, Mariya; Hardy, John; Inal, Jameel M (2017-06-05)Exosomes and microvesicles (EMVs) are lipid bilayer-enclosed structures released from cells and participate in cell-to-cell communication via transport of biological molecules. EMVs play important roles in various pathologies, ... -
Treatment of Prostate Cancer Using Deimination Antagonists and Microvesicle Technology.
Lange, Sigrun; Kholia, Sharad; Kosgodage, Uchini S; Inal, Jameel (Springer Nature, 2017)Cellular microvesicle (MV) release, which occurs in most eukaryotic cells, is also involved in cancer progression and has recently been associated with peptidylarginine deiminase (PAD)-driven protein deimination. Evidence ...