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Browsing by Author "Kozielewicz, Pawel"
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Insights into mechanism of anticancer activity of pentacyclic oxindole alkaloids of Uncaria tomentosa by means of a computational reverse virtual screening and molecular docking approach
Kozielewicz, Pawel; Paradowska, Katarzyna; Eric, Slavica; Wawer, Iwona; Zloh, Mire (2014-07-01)Alkaloid-rich extract from Uncaria tomentosa (eng. Cat’s claw) has been reported to cause apoptosis in vitro in cancer lines. Oxindole pentacyclic alkaloids of the plant are responsible for this effect, yet their biological ... -
β-Nitroso-o-Quinone Methides: Potent Intermediates in Organic Chemistry and Biology : The impact of the NO group on their Structure and Reactivity Profile: a Theoretical Insight
Kozielewicz, Pawel; Tsoungas, Petros; Zloh, Mire; Tzeli, Demeter; Petsalakis, Ioannis (2014-12)The structure and reactivity profile of prototype o-quinone methides 1, 2 and their ß-nitroso analogues 6-9 have been investigated by means of DFT and MP2 calculations. These highly reactive unstable species are generated ...