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Browsing by Author "Lee, David"
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Association between mouse nude gene expression and the initiation of epithelial terminal differentiation
Lee, David; Prowse, David M.; Brissette, Janice L. (1999-04-15)Loss-of-function mutations in Whn (Hfh 11), a winged-helix/forkhead transcription factor, result in the nude mouse phenotype. To determine the whn expression pattern during development, we utilized mice in which a β- ... -
Ectopic expression of the nude gene induces hyperproliferation and defects in differentiation : Implications for the self-renewal of cutaneous epithelia
Prowse, David M.; Lee, David; Weiner, Lorin; Jiang, Nanyan; Magro, Cynthia M.; Baden, Howard P.; Brissette, Janice L. (1999-08-01)Nude mice are characterized by the absence of visible hair, epidermal defects, and the failure to develop a thymus. This phenotype results from loss-of-function mutations in Whn (Hfh11), a winged-helix transcription factor. ...