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Browsing by Author "Leiper, J.M."
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Discovery of inhibitors of the pentein superfamily protein dimethylarginine dimethylaminohydrolase (DDAH), by virtual screening and hit analysis
Hartzoulakis, B.; Rossiter, S.; Gill, H.; Steinke, E.; Gane, P.J.; Hurtado-Guerrero, R.; Leiper, J.M.; Vallance, P.; Murray-Rust, J.; Selwood, D.L. (2007) -
Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolase
Rossiter, S.; Smith, C.L.; Malaki, M.; Nandi, M.; Gill, H.; Leiper, J.M.; Vallance, P.; Selwood, D.L. (2005)The enzyme DDAH metabolizes methylarginines that are inhibitors of nitric oxide synthase (NOS). Substrate-based inhibitors of mammalian DDAH have been synthesized, with optimization to give selective inhibition of DDAH ...