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Browsing by Author "Leiper, James"
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Disruption of methylarginine metabolism impairs vascular homeostasis
Leiper, James; Nandi, Manasi; Torondel, Belen; Murray-Rust, Judith; Malaki, Mohammed; O'Hara, Bernard; Rossiter, Sharon; Anthony, Shelagh; Madhani, Melanie; Selwood, David; Smith, Caroline; Wojciak-Stothard, Beata; Rudiger, Alain; Stidwill, Ray; McDonald, Neil Q.; Vallance, Patrick (2007-02)Asymmetric dimethylarginine (ADMA) and monomethyl arginine (L-NMMA) are endogenously produced amino acids that inhibit all three isoforms of nitric oxide synthase (NOS)(1). ADMA accumulates in various disease states, ... -
Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine : novel explanation of cardiovascular side effects associated with anti-inflammatory drugs
Ahmetaj-Shala, Blerina; Kirkby, Nicholas S.; Knowles, Rebecca; Al'Yamani, Malak; Mazi, Sarah; Wang, Zhen; Tucker, Arthur T.; Mackenzie, Louise; Armstrong, Paul C. J.; Nüsing, Rolf M.; Tomlinson, James A. P.; Warner, Timothy D.; Leiper, James; Mitchell, Jane A. (2015-02-17)BACKGROUND: Cardiovascular side effects associated with cyclooxygenase-2 inhibitor drugs dominate clinical concern. Cyclooxygenase-2 is expressed in the renal medulla where inhibition causes fluid retention and increased ... -
Guanidine derivatives as inhibitors of DDAH
Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Unit; Centre for Research in Mechanisms of Disease and Drug Discovery; Natural Product Chemistry and Drug Design; Department of Clinical, Pharmaceutical and Biological Science; Centre for Health Services and Clinical Research; School of Life and Medical Sciences; Rossiter, Sharon; Vallance, Patrick; Leiper, James; Selwood, David; Hartzoulakis, Basil (2009) -
Reply to Letter Regarding Article, "Evidence That Links Loss of Cyclooxygenase-2 With Increased Asymmetric Dimethylarginine : Novel Explanation of Cardiovascular Side Effects Associated With Anti-Inflammatory Drugs"
Ahmetaj-Shala, Blerina; Kirkby, Nicholas S.; Knowles, Rebecca; Al'Yamani, Malak; Mazi, Sara; Wang, Zhen; Tucker, Arthur T.; Mackenzie, Louise Susan; Armstrong, Paul C. J.; Nüsing, Rolf M.; Tomlinson, James A. P.; Warner, Timothy D.; Leiper, James; Mitchell, Jane A. (2015-10-27)