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Browsing by Author "Locker, K."
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Identification of metabolites of a substance P (Neurokinin 1 receptor) antagonist in rat hepatocytes and rat plasma
Hop, C.E.C.A.; Wang, Y.; Kumar, S.; Elipe, M.V.S.; Raab, C.E.; Dean, D.C.; Poon, G.K.; Keohane, C.-A.; Strauss, J.; Chiu, S.-H.L.; Curtis, N.; Elliott, J.; Gerhard, U.; Locker, K.; Morrison, D.; Mortishire-Smith, R.; Thomas, S.; Watt, A.P.; Evans, D.C. (2002-01-01)[3R,5R,6S]-3-(2-cyclopropyloxy-5-trifluoromethoxyphenyl)-6-phenyl-1-oxa-7 -azaspiro[4.5]decane is a substance P (Neurokinin 1 receptor) antagonist. Substance P antagonists are proven in concept to have excellent potential ... -
Identification of metabolites of a substance P (NK1 receptor) antagonist in rat hepatocytes and rat plasma
Hop, C.E.C.A.; Wang, Y.; Kumar, S.; Elipe, M.V.S.; Raab, C.E.; Dean, D.C.; Poon, G.K.; Keohane, C.-A.; Strauss, J.; Chiu, S.-H.L.; Curtis, N.; Elliott, J.; Gerhard, U.; Locker, K.; Morrison, D.; Mortishire-Smith, R.; Watt, A.P.; Evans, D.C. (2002-01-01)The metabolism of a substance P (NK1 receptor) antagonist in rat hepatocytes and rat plasma was described. The samples were prepared for analysis by protein precipitation followed by centrifugation. It was shown that the ...