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Browsing by Author "MacKenzie, Louise"
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Aspirin triggered 15-epi-lipoxin A4 predicts cyclo-oxygenase-2 in the lungs of LPS treated mice but not in the circulation : implications for a clinical test
Kirkby, Nick; Chan, M.V.; Lundberg, M.H.; MacKenzie, Louise; Leadbeater, Phillip D.M.; Milne, Ginger L.; Potter, Claire M.; Al-Yamani, Malak; Adeyemi, Oladipupo; Warner, Tim D.; Mitchell, Jane A. (2013-10)Inhibition of cyclooxygenase (COX)-2 increases cardiovascular deaths. Identifying a biomarker of COX-2 is desirable but difficult, since COX-1 and COX-2 ordinarily catalyze formation of an identical product, prostaglandin ... -
The effects of organ culture on contractility and PLC delta 1 expression in rat mesenteric arteries
MacKenzie, Louise; Hughes, A.D.; Lymn, Joanne (2002-10) -
LC-MS/MS Confirms That COX-1 Drives Vascular Prostacyclin Whilst Gene Expression Pattern Reveals Non-Vascular Sites of COX-2 Expression
Kirkby, N.S.; Zaiss, A.K.; Urquhart, P.; Jiao, J.; Austin, P.J.; Al-Yamani, Malak; Lundberg, M.H.; MacKenzie, Louise; Warner, T.D.; Nicolaou, A.; Herschman, H.R.; Mitchell, J.A. (2013-07-09)There are two schools of thought regarding the cyclooxygenase (COX) isoform active in the vasculature. Using urinary prostacyclin markers some groups have proposed that vascular COX-2 drives prostacyclin release. In contrast, ... -
Methylglyoxal, A Metabolite Increased in Diabetes is Associated with Insulin Resistance, Vascular Dysfunction and Neuropathies
Shamsaldeen, Yousif; MacKenzie, Louise; Lione, Lisa; Benham, Christopher (2016-05)Background: Diabetes mellitus (DM) is a pandemic metabolic disease characterized by a chronically elevated blood glucose concentration (hyperglycemia) due to insulin dysfunction. Approximately 50% of diabetics show diabetes ... -
NADPH oxidase is the source of ROS in STZ rat aorta : use of the novel highly selective NOX inhibitor VAS2870
Dugic, Elma; Shamsaldeen, Yousif; Benham, Christopher David; MacKenzie, Louise (2013-09)Abnormal vascular responsiveness in diabetes has been attributed to a number of changes in contractile and dilatory pathways, affected in part by the overproduction of reactive oxygen species (ROS). It has been reported ... -
An overview of anti-diabetic plants used in Gabon: Pharmacology and Toxicology
Bading-Taika, Bayissi; Bouckandou, M; De Souza, Alain; Bourobou Bourobou, H.P.; MacKenzie, Louise; Lione, Lisa (2018-04-24)Ethnopharmacological relevance: The management of diabetes mellitus management in African communities, especially in Gabon, is not well established as more than 60% of population rely on traditional treatments as primary ...