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Leptin-based hexamers facilitate memory and prevent amyloid-driven AMPA receptor internalisation and neuronal degeneration
Doherty, Gayle; Holiday, Alison; Malekizadeh, Yasaman; Manolescu, Cosmin; Duncan, Stephen; Flewitt, Iona; Hamilton, Kirsty; MacLeod, Beth; Ainge, James, A; Harvey, Jenni (2022-11-29)Key pathological features of Alzheimer's disease (AD) include build-up of amyloid β (Aβ), which promotes synaptic abnormalities and ultimately leads to neuronal cell death. Metabolic dysfunction is known to influence the ...