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Browsing by Author "Mahendran, Rhamiya"
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High Content Image Analysis as a Tool to Morphologically Distinguish Macrophage Activation and Determine Its Importance for Foamy Alveolar Macrophage Responses
Hoffman, Ewelina; Napieralska, Paulina; Mahendran, Rhamiya; Murnane, Darragh; Hutter, Victoria (2021-09-01)Introduction: Lung diseases are an increasing global health burden affecting millions of people worldwide. Only a few new inhaled medicines have reached the market in the last 30 years, in part due to foamy alveolar ... -
Morphometric Characterization of Rat and Human Alveolar Macrophage Cell Models and their Response to Amiodarone using High Content Image Analysis
Hoffman, Ewelina; Bodhaniya, Aateka; Ball, Doug; Klapwijk, Jan; Millar, Val; Kumar, Abhinav; Martin, Abigail; Mahendran, Rhamiya; Dailey, Lea Ann; Forbes, Ben; Hutter, Victoria (2017-12-31)Purpose. Progress to the clinic may be delayed or prevented when vacuolated or “foamy” alveolar macrophages are observed during non-clinical inhalation toxicology assessment. The first step in developing methods to study ... -
Profiling alveolar macrophage responses to inhaled compounds using in vitro high content image analysis
Hoffman, Ewelina; Urbano, Laura; Martin, Abigail; Mahendran, Rhamiya; Patel, Aateka; Murnane, Darragh; Page, Clive; Dailey, Lea Ann; Forbes, Ben; Hutter, Victoria (2023-09-01)One of the main hurdles in the development of new inhaled medicines is the frequent observation of foamy macrophage (FM) responses in non-clinical studies in experimental animals, which raises safety concerns and hinders ...