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Browsing by Author "Makwana, R."
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Evidence for both inverse agonism at the cannabinoid CB1 receptor and the lack of an endogenous cannabinoid tone in the rat and guinea-pig isolated ileum myenteric plexus-longitudinal muscle preparation
Makwana, R.; Molleman, A.; Parsons, M. (2010)Background and purpose: Cannabinoid receptor agonists reduce intestinal propulsion in rodents through the CB1 receptor. In addition to its antagonistic activity at this receptor, rimonabant (N-(piperidino)-5-(4-chlorophe ... -
Pharmacological Analysis of Cannabinoid Receptor Activity in Isolated Nerve-Smooth Muscle and Epithelial Preparations
Makwana, R. (2007-12-14)This study was directed at characterising the cannabinoid receptor activity modulating the electrical field stimulation (EFS) evoked contractions of the rat isolated ileum myenteric plexus longitudinal muscle (MPLM) ... -
Pharmacological characterization of cannabinoid receptor activity in the rat-isolated ileum myenteric plexus-longitudinal muscle preparation
Makwana, R.; Molleman, A.; Parsons, M. (2010)Background and purpose: Cannabinoid effects on intestinal transit are commonly evaluated in rats. We characterized the cannabinoid receptors mediating the inhibitory effect of 5-(1,1-dimethylheptyl)-2-[5-hydroxy-2-(3-hyd ... -
The short circuit of the ileum but not the colon is altered in the streptozotocin diabetic rat
Forrest, A.; Makwana, R.; Parsons, M. (2006)