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Browsing by Author "Maplestone, R.A."
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Dissection of the contributions toward dimerization of glycopeptide antibiotics
Mackay, J.P.; Gerhard, U.; Beauregard, D.A.; Maplestone, R.A.; Williams, D.H. (1994-06-01)A procedure for the determination of association constants in aqueous solution using hydrogen-deuterium exchange has been developed and used to measure the dimerization constant, K(dim), for a number of strongly dimerizing ... -
The role of the sugar and chlorine substituents in the dimerization of vancomycin antibiotics
Gerhard, U.; Mackay, J.P.; Maplestone, R.A.; Williams, D.H. (1993-01-01) -
Toward an estimation of binding constants in aqueous solution : Studies of associations of vancomycin group antibiotics
Williams, D.H.; Searle, M.S.; Mackay, J.P.; Gerhard, U.; Maplestone, R.A. (1993-01-01)An approach toward the estimation of binding constants for organic molecules in aqueous solution is presented, based upon a partitioning of the free energy of binding. Consideration is given to polar and hydrophobic ...