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Browsing by Author "Marton, John"
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Differential dose–response effect of cyclosporine A in regulating apoptosis and autophagy markers in MCF-7 cells
Siddiqui, Shoib; Hodeify, Rawad; Mathew, Shimy; Alsawaf, Seba; Alghfeli, Anood; Matar, Rachel; Merheb, Maxime; Marton, John; Al Zouabi, Hussain AbdulKarim; Muthuirulandi Sethuvel, Dhiviya Prabaa; Devanga Ragupathi, Naveen Kumar; Vazhappilly , Cijo George (2023-05-19)Cyclosporine A (CsA) is an immunosuppressant primarily used at a higher dosage in transplant medicine and autoimmune diseases with a higher success rate. At lower doses, CsA exhibits immunomodulatory properties. CsA has ... -
Mitochondrial DNA, a Powerful Tool to Decipher Ancient Human Civilization from Domestication to Music, and to Uncover Historical Murder Cases
Merheb, Maxime; Matar, Rachel; Hodeify, Rawad; Siddiqui, Shoib Sarwar; Vazhappilly, Cijo George; Marton, John; Azharuddin, Syed; Al Zouabi, Hussain (2019-05-09)Mitochondria are unique organelles carrying their own genetic material, independent from that in the nucleus. This review will discuss the nature of mitochondrial DNA (mtDNA) and its levels in the cell, which are the key ... -
Modulation of calcium-binding proteins expression and cisplatin chemosensitivity by calcium chelation in human breast cancer MCF-7 cells
Hodeify, Rawad; Siddiqui, Shoib Sarwar; Matar, Rachel; Vazhappilly, Cijo George; Merheb, Maxime; Al Zouabi, Hussain; Marton, John (2021-01-22)Cisplatin (CDDP) is currently one of the most effective FDA-approved treatments for breast cancer. Previous studies have shown that CDDP-induced cell death in human breast cancer (MCF-7) cells is associated with disruption ...