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Browsing by Author "Moore, Colin"
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The emerging role of exosome and microvesicle- (EMV-) based cancer therapeutics and immunotherapy
Moore, Colin; Kosgodage, Uchini; Lange, Sigrun; Inal, Jameel M (2017-08-01)There is an urgent need to develop new combination therapies beyond existing surgery, radio- and chemo-therapy, perhaps initially combining chemotherapy with the targeting specificities of immunotherapy. For this, strategies ... -
Microvesicles released constitutively from prostate cancer cells differ biochemically and functionally to stimulated microvesicles released through sublytic C5b-9
Stratton, Dan; Moore, Colin; Antwi-Baffour, Samuel; Lange, Sigrun; Inal, Jameel (2015-05-08)We have classified microvesicles into two subtypes: larger MVs released upon stimulation of prostate cancer cells, sMVs, and smaller cMVs, released constitutively. cMVs are released as part of cell metabolism and sMVs, ... -
Prostate cancer cells stimulated by calcium-mediated activation of protein kinase C undergo a refractory period before re-releasing calcium-bearing microvesicles
Stratton, Dan; Moore, Colin; Zheng, Lei; Lange, Sigrun; Inal, Jameel (2015-05-08)MVs are released in response to several stress agents, in an attempt to prevent continued cellular damage. After an initial stimulus of prostate cancer cells with sublytic C5b-9 and activation of MV release through PKC, ...