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Browsing by Author "Murdan, S."
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The effect of disulphide bond disruption on the barrier integrity of the human nail
Baraldi, A.; Khengar, R.H.; Murdan, S.; Traynor, M.J.; Jones, S.A.; Brown, Marc (Royal Society of Chemistry, 2014-04-14)Onychomycosis is the fungal infection of the nail and accounts for approximately 50% of all nail disorders [1]. The prevalence of onychomycosis is increasing and currently up to 10 % of people in the UK and US are reported ... -
Human Nail Plate Modifications Induced by Onychomycosis : Implications for Topical Therapy
Baraldi, A.; Jones, S. A.; Guesné, S.; Traynor, M.J.; McAuley, W. J.; Brown, Marc; Murdan, S. (2015-05-01)Conclusions: Onchomycotic nails presented a thicker but more porous barrier, and its eroded intracellular matrix rendered the tissue more permeable to topically applied chemicals when an aqueous vehicle was used.Purpose: ... -
An investigation of how fungal infection influences drug penetration through onychomycosis patient's nail plates
McAuley, W. J.; Jones, S. A.; Traynor, M.J.; Guesné, S.; Murdan, S.; Brown, Marc (2016-05)The treatment of onychomycosis remains problematic even though there are several potent antifungal agents available for patient use. The aim of this investigation was to understand if the structural modifications that arise ...