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Browsing by Author "Mwangi, Shaban"
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Extracellular vesicles could be a putative posttranscriptional regulatory mechanism that shapes intracellular RNA levels in Plasmodium falciparum
Kioko, Mwikali; Pance, Alena; Mwangi, Shaban; Goulding, David; Kemp, Alison; Rono, Martin; Ochola-Oyier, Lynette Isabella; Bull, Pete C.; Bejon, Philip; Rayner, Julian C.; Abdi, Abdirahman I. (2023-10-13)Plasmodium falciparum secretes extracellular vesicles (PfEVs) that contain parasite-derived RNA. However, the significance of the secreted RNA remains unexplored. Here, we compare secreted and intracellular RNA from asexual ... -
The mRNA content of plasma extracellular vesicles provides a window into the brain during cerebral malaria disease progression
Abdi, Abdirahman; Mwikali, Kioko; Mwangi, Shaban; Pance, Alena; Ochola-Oyier, Lynette; Kariuki, Symon; Newton, Charles; Bejon, Philip; Rayner, Julian (2023-09-28)The impact of cerebral malaria on the transcriptional profiles of cerebral tissue is difficult to study using non-invasive approaches. We isolated plasma extracellular vesicles (EVs) from patients with cerebral malaria and ...