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Browsing by Author "Mwikali, Kioko"
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The mRNA content of plasma extracellular vesicles provides a window into the brain during cerebral malaria disease progression
Abdi, Abdirahman; Mwikali, Kioko; Mwangi, Shaban; Pance, Alena; Ochola-Oyier, Lynette; Kariuki, Symon; Newton, Charles; Bejon, Philip; Rayner, Julian (2023-09-28)The impact of cerebral malaria on the transcriptional profiles of cerebral tissue is difficult to study using non-invasive approaches. We isolated plasma extracellular vesicles (EVs) from patients with cerebral malaria and ... -
Novel stem cell technologies are powerful tools to understand the impact of human factors on Plasmodium falciparum malaria
Pance, Alena; Ng, Bee Ling; Mwikali, Kioko; Koutsourakis, Manousos; Agu, Chukwuma; Rouhani, Foad J.; Montandon, Ruddy; Law, Frances; Ponstingl, Hannes; Rayner, Julian C. (2023-12-19)Plasmodium falciparum parasites have a complex life cycle, but the most clinically relevant stage of the disease is the invasion of erythrocytes and the proliferation of the parasite in the blood. The influence of human ...