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Browsing by Author "Natural Product Chemistry and Drug Design"
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5,6-Methylenedioxy-2-aminoindane : from laboratory curiosity to 'legal high'
Gallagher, C. T.; Assi, S.; Stair, J. L.; Fergus, S.; Corazza, Ornella; Corkery, John; Schifano, Fabrizio (2012-03-01)The fully synthetic 'legal high' 5,6-methylenedioxy-2-aminoindane (MDAI) is an analogue of 3,4-methylenedioxymethamphetamine. Although developed in the 1990s, it was not widely abused until 2010. However, mephedrone was ... -
Analysis of 'legal high' substances and common adulterants using handheld spectroscopic techniques
Assi, Sulaf; Guirguis, Amira; Halsey, S.; Fergus, S.; Stair, J. L. (2015-01)The identification of 'legal highs' is challenging as they often do not match their label claim and contain a wide range of impurities and/or adulterants. In addition, there is a need for techniques to be on-site, rapid ... -
Anthracene based compounds and their uses
School of Life and Medical Sciences; Natural Product Chemistry and Drug Design; Centre for Research into Topical Drug Delivery and Toxicology; Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Unit; Centre for Health Services and Clinical Research; Centre for Research in Mechanisms of Disease and Drug Discovery; Department of Clinical, Pharmaceutical and Biological Science; Rossiter, Sharon; Kirton, Stewart; Camara, Ramatoulie (2016-11-17) -
Are undergraduate students studying smart? Insights into study strategies and habits across a programme of study
Fergus, Suzanne (2022-04-08)The approach that students take in their studies at university is critical not only for their academic success but is equally important in life-long learning for their career and professional development. Heutagogy is the ... -
The benefits of in silico modeling to identify possible small-molecule drugs and their off-target interactions
Zloh, Mire; Kirton, Stewart (2018-02-01)The research into the use of small molecules as drugs continues to be a key driver in the development of molecular databases, computer-aided drug design software and collaborative platforms. The evolution of computational ... -
Bicyclic 6-6 Systems: Pteridines
Rossiter, Sharon; Ostovar, Mehrnoosh (Elsevier, 2022)This article describes the literature on pteridines, covering the period from 2008 to 2020. The physical properties and reactions include photochemistry, substitution at ring nitrogens, nucleophilic substitution at ring ... -
A cellulose-based bioassay for the colorimetric detection of pathogen DNA
Saikrishnan, Deepika; Goyal, Madhu; Rossiter, Sharon; Kukol, A. (2014-12-01)Cellulose-paper-based colorimetric bioassays may be used at the point of sampling without sophisticated equipment. This study reports the development of a colorimetric bioassay based on cellulose that can detect pathogen ... -
Comparative modelling of cytochromes P450
Kirton, S. B.; Baxter, C. A.; Sutcliffe, M. J. (2002-03-31)The superfamily of enzymes known as the cytochromes P450 (P450s) comprises a wide-ranging class of proteins with diverse functions. They are known, amongst other things, to be involved in the hormonal regulation of metabolism ... -
A comparison of novel N(G),N(G)-disubstituted arginines on recombinant dimethylarginine dimethylaminohydrolase-1 activity and nitrite production in RAW264.7 macrophages
Morfill, Corinne; Rossiter, Sharon; Smith, Caroline (2012) -
Copper (II) mediated arylation with aryl boronic acids for the N-derivatization of pyrazole libraries
Rossiter, S.; Woo, C.K.; Hartzoulakis, B.; Wishart, G.; Stanyer, L.; Labadie, J.W.; Selwood, D.L. (2004)A N-derivatized 3-dimethylaminopropyloxypyrazole library was prepared using solution-phase parallel synthesis. The library was designed using physicochemical constraints designed to remove non-membrane-permeable molecules. ... -
Demethylation of 2,4-dimethoxquinolines: the synthesis of atanine
Jones, K.; Roset, X.; Rossiter, S.; Whitfield, P.J. (2003) -
Design, Synthesis and Antimicrobial Evaluation of the in vitro Efficacy of Novel Diketones
Garikipati, Rajesh; Mohammed, Olufunmilayo; Rossiter, Sharon; Baines, Simon; Bassin, Jatinder; Goyal, Madhu (2015-11-26)A series of novel diketones were designed and synthesised in an attempt to develop potent antimicrobial agents. Their structures were confirmed by spectroscopic techniques i.e. 1H and 13C-NMR, IR and LC-MS. The minimum ... -
A Design-of-Experiments Approach to Developing Thermoresponsive Gelators From Complex Polymer Mixtures
Kirton, Stewart; Stair, Jacqueline; Abou Shamat, Mohamad; Calvo-Castro, Jesus; Cook, Michael T. (2020-10-13)This study investigated the effects of additives on the properties of poloxamer (P) 407 thermogels, employing a design-of-experiments (DoE) approach. P407 is a thermoresponsive triblock copolymer that exhibits a solution ... -
Detection of Newly Emerging Psychoactive Substances Using Raman Spectroscopy and Chemometrics
Calvo-Castro, Jesus; Guirguis, Amira; Samaras, Eleftherios; Zloh, Mire; Kirton, Stewart; Stair, Jacqueline (2018-09-12)A novel approach for the identification of New Psychoactive Substances (NPS) by means of Raman spectroscopy coupled with Principal Components Analysis (PCA) employing the largest dataset of NPS reference materials to date ... -
Discovery of inhibitors of the pentein superfamily protein dimethylarginine dimethylaminohydrolase (DDAH), by virtual screening and hit analysis
Hartzoulakis, B.; Rossiter, S.; Gill, H.; Steinke, E.; Gane, P.J.; Hurtado-Guerrero, R.; Leiper, J.M.; Vallance, P.; Murray-Rust, J.; Selwood, D.L. (2007) -
Discovery of novel small molecule inhibitors of S100P, with in vitro anti-metastatic effects on pancreatic cancer cells
Camara, Ramatoulie; Ogbeni, Deborah; Gerstmann, Lisa; Ostovar, Mehrnoosh; Hurer, Ellie; Scott, Mark; Mahmoud, Nasir; Radon, Tomasz; Crnogorac-Jurcevic, Tatjana; Patel, Pryank; Mackenzie, Louise Susan; Chau, David; Kirton, Stewart; Rossiter, Sharon (2020-10-01)S100P, a calcium- binding protein, is known to advance tumor progression and metastasis in pancreatic and several other cancers. Herein is described the in silico identification of a putative binding pocket of S100P to ... -
Disruption of methylarginine metabolism impairs vascular homeostasis
Leiper, James; Nandi, Manasi; Torondel, Belen; Murray-Rust, Judith; Malaki, Mohammed; O'Hara, Bernard; Rossiter, Sharon; Anthony, Shelagh; Madhani, Melanie; Selwood, David; Smith, Caroline; Wojciak-Stothard, Beata; Rudiger, Alain; Stidwill, Ray; McDonald, Neil Q.; Vallance, Patrick (2007-02)Asymmetric dimethylarginine (ADMA) and monomethyl arginine (L-NMMA) are endogenously produced amino acids that inhibit all three isoforms of nitric oxide synthase (NOS)(1). ADMA accumulates in various disease states, ... -
Drowning in Diversity? A systematic way of clustering a representative set of new psychoactive substances
Zloh, Mire; Samaras, Eleftherios; Calvo-Castro, Jesus; Guirguis, Amira; Stair, Jacqueline; Kirton, Stewart (2017-11-17)New psychoactive substances (NPS) can be generally described as a set of compounds that have been designed to mimic the effects of illegal recreational drugs, but are not subject to restriction or control with respect to ... -
The eggshell membrane : A potential biomaterial for corneal wound healing
Mensah, Rosemond A; Jo, Seung Bin; Kim, Hoon; Park, Sung-Min; Patel, Kapil D; Cho, Kyong J; Cook, Michael T; Kirton, Stewart B; Hutter, Victoria; Sidney, Laura E; Alves-Lima, Decio; Lin, Hungyen; Lee, Jung-Hwan; Kim, Hae-Won; Chau, David Ys (2021-11-30)The eggshell membrane (ESM) is an abundant resource with innate complex structure and composition provided by nature. With at least 60 million tonnes of hen eggs produced globally per annum, utilisation of this waste ...