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Browsing by Author "Neil, Spooner,"
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Direct Ionization of Solid-Phase Microextraction Fibers for Quantitative Drug Bionalysis : From Peripheral Circulation to Mass Spectrometry Detection
Sheelan, Ahmad,; Michael, Tucker,; Neil, Spooner,; Murnane, Darragh; Gerhard, Ute (2015-01-06)A novel approach is described for the quantitative bioanalysis of drugs in blood samples by ionization of the analytes collected on solid-phase microextraction (SPME) fibers by mass spectrometry (MS). The technique combines ... -
Solid-phase microextraction for assessment of plasma protein binding, a complement to rapid equilibrium dialysis
Sheelan, Ahmad,; Baker, Daniel; Murnane, Darragh; Neil, Spooner,; Gerhard, Ute (2021-07-19)Aim: Determination of plasma protein binding (PPB) is considered vital for better understanding of pharmacokinetic and pharmacodynamic activities of drugs due to the role of free concentration in pharmacological response. ...